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Neuroprostanes

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The neuroprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily docosahexaenoic acid) without the direct action of cyclooxygenase (COX) enzymes. The result is the formation of isoprostane-like compounds F4-, D4-, E4-, A4-, and J4-neuroprostanes which have been shown to be produced in vivo. These oxygenated essential fatty acids possess potent biological activity as anti-inflammatory mediators inhibiting the response of human macrophages that augment the perception of pain.


See also

References

  1. Jacson, Roberts (2005). "The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation". Brain Pathology. 15 (2): 143–148. doi:10.1111/j.1750-3639.2005.tb00511.x. PMC 8095955. PMID 15912887. S2CID 43236072.
  2. Gladine, Laurie (2014). "Neuroprostanes, produced by free-radical mediated peroxidation of DHA, inhibit the inflammatory response of human macrophages" (PDF). Free Radic. Biol. 75 (S1): S15. doi:10.1016/j.freeradbiomed.2014.10.590. PMID 26461294.


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