Article snapshot taken from Wikipedia with creative commons attribution-sharealike license.
Give it a read and then ask your questions in the chat.
We can research this topic together.
Chiorazzi's research interests revolve around understanding the activation and maturation of B-lymphocytes in health and disease, in particular chronic lymphocytic leukemia (CLL). Chiorazzi and his colleagues have demonstrated that: CLL cells are responsive to the signals from the internal microenvironment, specifically, those delivered by the B-cell antigen receptor (BCR) leading to leukemic cell proliferation and maturation or death; BCR-induced signals are likely delivered by common self-antigens and are mediated through sets of BCRs of remarkably similar amino acid structure; patients with CLL segregate into two subgroups based on BCR structure that differ dramatically in the clinical outcome; CLL cells proliferate and die in vivo at rates higher than originally appreciated. These findings have led to the view that (auto)antigen drive is a promoting factor in the development and evolution of CLL and has been pivotal in refining patient prognosis.
