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Nicholas Mrosovsky

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Canadian zoologist (1934–2015)
Nicholas Mrosovsky
Born(1934-03-03)March 3, 1934
Romania
DiedFebruary 22, 2015(2015-02-22) (aged 80)
Toronto, Canada
EducationMagdalene College, Cambridge
University College London
SpouseSara Shettleworth
Children2
Scientific career
InstitutionsUniversity of Toronto

Nicholas Mrosovsky (3 March 1934 – 22 February 2015) was a Canadian zoologist known for his research in the fields of homeostasis, chronobiology, and sea turtle biology. He spent his whole professional career at the University of Toronto. His laboratory was notable for its seminal investigations of the influence of behavioural arousal on circadian rhythms. He was also the founder, in 1976, of Marine Turtle Newsletter. He received a Guggenheim Fellowship in 1973, and in 1993 he was elected a Fellow of the Royal Society of Canada.

Early life and education

Mrosovsky was born in 1934 in Romania, to British parents. He was educated at Winchester College in England. He received an undergraduate degree from Magdalene College, Cambridge, and a PhD from University College London. In 1967 he joined the Department of Zoology at the University of Toronto, where he spent his entire career, with cross-appointments to the Department of Psychology and to the Department of Physiology.

Work on homeostasis

Much of Mrosovsky's early research was concerned with the regulation of body weight, in hibernators at first and then in other animals. Together with graduate student David Sherry and colleague Jerry Hogan, he showed that lone incubating birds lose body weight throughout incubation not because of a lack of feeding opportunities but rather because it is programmed in them, the setpoint for body weight slowly decreasing until the end of the incubation period, an adaptation to minimize the time budget conflict between feeding and incubation duties.

Work in chronobiology

Mrosovky's early work on weight regulation during hibernation led to studies on circannual rhythms. With graduate student Janet Joy he found that endogenous circannual rhythms of body weight and molt in golden-mantled ground squirrels and in thirteen-lined ground squirrels could be delayed by cold temperatures in the spring, suggesting that spring temperatures in nature can help synchronize the period of circannual rhythms in hibernators to an annual periodicity.

From these first forays into chronobiology, Mrosovsky's lab developed a productive research program on circadian rhythms, specializing on how golden hamster circadian rhythms of activity could be entrained or shifted by non-photic factors such as social interaction, socio-sexual cues, and novelty-induced wheel-running. The latter factor was later shown to also be effective in a diurnal mammal, the European ground squirrel. The phase-shifting effects of strong behavioural arousal (as confirmed by running activity) is robust and further studies from the Mrosovsky lab showed that it in fact mediates the action of other stimuli on circadian rhythms, such as the benzodiazepine triazolam and pulses of darkness given on a background of constant light. He also interpreted the effects of behavioural arousal in the context of possible masking (or direct effects on the output of the circadian clock rather than on the clock itself) and of clock gene expression.

Work on sea turtles

Mrosovsky's early research included the study of phototaxis, first in frogs and then in turtles. This led to his and his wife Sara Shettleworth’s experimental demonstration that young sea turtles, freshly emerged from their nest on a beach, use luminosity to find the sea, the sky over the sea always being brighter than the vegetation-rimmed beach edge inland. There followed further studies on the visual system of turtle hatchlings, and on the influence of temperature on sex ratio, nest selection, and nest emergence in sea turtles.

His interest in sea turtles expanded to issues of conservation. For more than four decades he was an active member of the IUCN-SSC Marine Turtle Specialist Group. He founded the quarterly periodical Marine Turtle Newsletter in 1976. He did not shy away from expressing contentious opinions, such as the possibility of harvesting sea turtles in a sustainable way. and a criticism of the IUCN for basing its listings of endangered species on information not publicly available.

Awards

Publications

Nicholas Mrosovsky authored four books and authored or co-authored more than 200 scientific articles. He also contributed several entries to the News & Views column of the scientific journal Nature, and numerous editorials in Marine Turtle Newsletter.

Books:

  • Mrosovsky, N. (1971). Hibernation and the Hypothalamus. New York: Springer.
  • Mrosovsky, N. (1983). Conserving Sea Turtles. London: British Herpetological Society.
  • Mrosovsky, N. (1990). Rheostasis: The Physiology of Change. New York: Oxford University Press.
  • Mrosovsky, N. (2000). Sustainable Use of Hawksbill Turtles: Contemporary Issues in Conservation. Darwin: Key Centre for Tropical Wildlife Management.

Notable papers:

  • Mrosovsky, N. (1962). "Changes in multilocular brown adipose tissue in the rat following hypothermia." Nature 196: 72–73. DOI: 10.1038/196072a0
  • Mrosovsky, N. (1966). "Plasticity of reactions to light in frogs and a possible role for the pineal eye." Nature 210: 1174–1175. DOI: 10.1038/2101174a0
  • Mrosovsky, N. (1968) "Nocturnal emergence of hatchling sea turtles: control by thermal inhibition of activity." Nature 220: 1338–1339. DOI: 10.1038/2201338a0
  • Frair, W., Ackman, R.G., Mrosovsky, N. (1972) "Body temperature of Dermochelys coriacea: warm turtle from cold water." Science 177: 791–793. DOI: 10.1126/science.177.4051.791
  • Mrosovsky, N. (1977) "Hibernation and body weight in dormice: a new type of endogenous cycle." Science 196: 902–903. DOI: 10.1126/science.860123
  • Mrosovsky, N., Sherry, D.F. (1980). "Animal anorexias." Science 207: 837–842. DOI: 10.1126/science.6928327
  • Mrosovsky, N., Hopkins-Murphy, S.R., Richardson, J.L. (1984). "Sex ratio of sea turtles: seasonal changes." Science 225: 739–741. DOI: 10.1126/science.225.4663.739
  • Mrosovsky, N., Salmon, P.A. (1987). "A behavioural method for accelerating re-entrainment of rhythms to new light-dark cycles." Nature 330: 372–373. DOI: 10.1038/330372a0

References

  1. Lakin-Thomas, P. (2015). "In memoriam: Nicholas Mrosovsky". Journal of Biological Rhythms. 30 (5): 359–363. doi:10.1177/0748730415602167. PMID 26359435. S2CID 32974966.
  2. Sherry, D.; Mrosovsky, N.; Hogan, J.A. (1980). "Weight loss and anorexia during incubation in birds". Journal of Comparative and Physiological Psychology. 94: 89–98. doi:10.1037/h0077647.
  3. Mrosovsky, N. (1980). "Circannual cycles in golden-mantled ground squirrels: Experiments with food deprivation and effects of temperature on periodicity". Journal of Comparative Physiology A. 136 (4): 355–360. doi:10.1007/BF00657357. S2CID 1307642.
  4. Joy, J.; Mrosovsky, N. (1983). "Circannual cycles in golden-mantled ground squirrels: Lengthening of period by low temperatures in the spring phase". Journal of Comparative Physiology A. 150 (2): 233–238. doi:10.1007/BF00606373. S2CID 24380073.
  5. Joy, J.; Mrosovsky, N. (1985). "Synchronization of circannual cycles: A cold spring delays the cycles of thirteen-lined ground squirrels". Journal of Comparative Physiology A. 156: 125–134. doi:10.1007/BF00610673. S2CID 24689315.
  6. Mrosovsky, N. (1988). "Phase response curves for social entrainment". Journal of Comparative Physiology A. 162 (1): 35–46. doi:10.1007/BF01342701. PMID 3351785. S2CID 1805802.
  7. Honrado, G.I..; Mrosovsky, N. (1989). "Arousal by sexual stimuli accelerates the re-entrainment of hamsters to phase advanced light-dark cycles". Behavioral Ecology and Sociobiology. 25: 57–63. doi:10.1007/BF00299711. S2CID 7076600.
  8. Reebs, S.G..; Mrosovsky, N. (1989). "Effects of induced wheel running on the circadian activity rhythms of Syrian hamsters: Entrainment and phase response curve". Journal of Biological Rhythms. 4 (1): 39–48. doi:10.1177/074873048900400103. PMID 2519579. S2CID 888120.
  9. Hut, R.A.; Mrosovsky, N.; Daan, S. (1999). "Nonphotic entrainment in a diurnal mammal, the European ground squirrel (Spermophilus citellus)". Journal of Biological Rhythms. 14 (5): 409–419. doi:10.1177/074873099129000812. PMID 10511008. S2CID 10501411.
  10. Mrosovsky, N.; Salmon, P.A. (1990). "Triazolam and phase-shifting acceleration re-evaluated". Chronobiology International. 7 (1): 35–41. doi:10.3109/07420529009056952. PMID 2372850.
  11. Reebs, S.G.; Lavery, R.J.; Mrosovsky, N. (1989). "Running activity mediates the phase-advancing effects of dark pulses on hamster circadian rhythms". Journal of Comparative Physiology A. 165 (6): 811–818. doi:10.1007/BF00610879. PMID 2810151. S2CID 21431397.
  12. Mrosovsky, N. (1999). "Masking: history, definitions, and measurement". Chronobiology International. 16 (4): 415–429. doi:10.3109/07420529908998717. PMID 10442236.
  13. Maywood, E.S.; Mrosovsky, N.; Field, M.D.; Hastings, M.H. (1999). "Rapid down-regulation of mammalian Period genes during behavioral resetting of the circadian clock". Proceedings of the National Academy of Sciences. 96 (26): 15211–15216. doi:10.1073/pnas.96.26.15211. PMC 24799. PMID 10611364.
  14. Boycott, B.B.; Mrosovsky, N.; Muntz, W.R. (1964). "Black and white preferences in the frog, Rana temporaria, and other anura". Journal of Experimental Biology. 41 (4): 865–877. doi:10.1242/jeb.41.4.865. PMID 14239914.
  15. Mrosovsky, N.; Tress, K.H. (1966). "Plasticity of reactions to light in frogs and a possible role for the pineal eye". Nature. 210 (5041): 1174–1175. doi:10.1038/2101174a0. PMID 5964185. S2CID 4277069.
  16. Mrosovsky, N.; Boycott, B.B. (1966). "Intra- and interspecific differences in phototactic behaviour of freshwater turtles". Behaviour. 26 (3–4): 215–227. doi:10.1163/156853965x00192. PMID 5933271.
  17. Mrosovsky, N.; Carr, A. (1967). "Preference for light of short wavelengths in hatchling green sea turtles, Chelonia mydas, tested on their natural nesting beaches". Behaviour. 28 (3–4): 217–231. doi:10.1163/156853967x00019. PMID 6038298.
  18. Mrosovsky, N.; Shettleworth, S.J. (1968). "Wavelength preferences and brightness cues in the water finding behaviour of sea turtles". Behaviour. 32 (4): 211–217. doi:10.1163/156853968x00216. PMID 5717260.
  19. Mrosovsky, N.; Shettleworth, S.J. (1974). "Further studies of the sea-finding mechanism in green turtle hatchlings". Behaviour. 51 (3–4): 195–208. doi:10.1163/156853974x00192. PMID 4447586.
  20. Godfrey, M.H. (2016). "In memoriam: Nicholas Mrosovsky (1934-2015)". Marine Turtle Newsletter. 148: 16.
  21. "About the Marine Turtle Newsletter".
  22. Mrosovsky, N. (1883). Conserving Sea Turtles. London: British Herpetological Society. ISBN 0950737119.
  23. Mrosovsky, N. (1997). "IUCN's credibility critically endangered". Nature. 389 (6650): 436. doi:10.1038/38873. S2CID 4389685.
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