Nicole Mitchell may refer to:
- Nicole Mitchell (cyclist) (born 1983), Bermudian road cyclist
- Nicole Mitchell (meteorologist) (born 1974), American meteorologist and politician from Minnesota
- Nicole Mitchell (musician) (born 1967), American jazz flautist
- Nikole Mitchell (born 1974), Jamaican sprinter
- K. Nicole Mitchell, magistrate judge of the U.S. District Court for the Eastern District of Texas
- Nicola Mitchell, fictional character from EastEnders
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