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Nipecotic acid

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Chemical compound Pharmaceutical compound
Nipecotic acid
Identifiers
IUPAC name
  • Piperidine-3-carboxylic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.007.159 Edit this at Wikidata
Chemical and physical data
FormulaC6H11NO2
Molar mass129.159 g·mol
3D model (JSmol)
SMILES
  • C1CC(CNC1)C(=O)O

Nipecotic acid is a GABA uptake inhibitor used in scientific research.

See also

References

  1. Macdonald, R.L. (2012). Eadie, Mervyn J.; Vajda, Frank J. E. (eds.). Antiepileptic drugs: pharmacology and therapeutics (First ed.). : Springer. p. 130. ISBN 978-3-642-64244-9. In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release.
  2. Takahashi K, Miyoshi S, Kaneko A, Copenhagen DR (1995). "Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina". Jpn. J. Physiol. 45 (3): 457–73. doi:10.2170/jjphysiol.45.457. PMID 7474528.
  3. Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures". Epilepsy Research. 86 (2–3): 113–23. doi:10.1016/j.eplepsyres.2009.05.008. PMID 19535226. S2CID 32999271.
GABATooltip γ-Aminobutyric acid metabolism and transport modulators
Transporter
GATTooltip GABA transporter
VIAATTooltip Vesicular inhibitory amino acid transporter
Enzyme
GADTooltip Glutamate decarboxylase
GABA-TTooltip γ-Aminobutyrate aminotransferase
Other
Antivitamin B6
See also
Receptor/signaling modulators
GABA receptor modulators
GABAA receptor positive modulators
Glutamate metabolism/transport modulators
Glycine receptor modulators
Receptor
(ligands)
GlyRTooltip Glycine receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Transporter
(blockers)
GlyT1Tooltip Glycine transporter 1
GlyT2Tooltip Glycine transporter 2
See also
Receptor/signaling modulators
GABA receptor modulators
GABAA receptor positive modulators
Ionotropic glutamate receptor modulators


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