Misplaced Pages

Niveen Khashab

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Lebanese chemist

Niveen M. Khashab is a Lebanese chemist and an associate Professor of chemical Sciences and engineering at King Abdullah University of Science and Technology in Saudi Arabia since 2009. She is a laureate of the 2017 L'Oréal-UNESCO Awards for Women in Science "for her contributions to innovative smart hybrid materials aimed at drug delivery and for developing new techniques to monitor intracellular antioxidant activity." She is also a fellow of the Royal Chemical Society, and a member of the American Chemical Society.

Education

Niveen M. Khashab received her B.S. in Chemistry from the American University of Beirut, Lebanon, followed by her PhD in chemistry at the University of Florida.

Research & Career

Professor Khashab's research focuses on the design, synthesis, and use of "smart" programmable nanomaterials, emphasizing the systems' controlled release and delivery characteristics. These synthetic materials are applied for biomimetic biological (distribution, sensing, and imaging), industrial (nanocomposites), and environmental (synthesis of membranes) applications, respectively. Niveen's research interests include leveraging the natural microporosity of supramolecular assemblies for energy-intensive separations. Her research team is particularly interested in the separation of benzene derivatives employing macrocycles and cages designed for optimal separation via molecular recognition. Her team has produced a variety of self-assembled capsules (SACs) for the encapsulation and transport of RNA, DNA, and proteins. She focuses on the encapsulation and delivery of CRISPR-Cas9 to enhance targeted gene editing.

With more than ten years of professional experience, Prof. Niveen M. Khashab is presently a Full Professor and Head of the Chemistry Program at the King Abdullah University of Science and Technology.

Bibliography

  • Carbon Nanomaterials Sourcebook: Graphene, Fullerenes, Nanotubes, and Nanodiamonds, Volume I.

Patents

Prof. Niveen M. Khashab has obtained many patents for her inventions including:

  • Compositions of graphene materials with metal nanostructures and microstructures and methods of making and using including pressure sensors (US10807048B2)
  • Magnetically controlled permeability membranes (US20180296469A1)
  • Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same (EP3471864A1)
  • Nanocluster capped mesoporous nanoparticles, methods of making and use (US20200046849A1)
  • Polymer carbon nanotube composite (US20160297952A1)
  • Polymer nanocomposites and methods of making nanocomposites (US9650494B2)
  • Separating aromatic isomers using aqueous solutions of cucurbituril macrocycles (WO2021124219A1)
  • Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same (US20200306701A1)
  • Encoding Raman spectral data in optical identification tags for analyte identification (WO2021053409A1)

Publications

  • Jonas G. Croissant, Yevhen Fatieiev, Niveen M. Khashab. "Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles". WIley Online Library.
  • Jonas G. Croissant, Yevhen Fatieiev, Abdulaziz Almalik, Niveen M. Khashab. "Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications". WIley Online Library.
  • Shahad K Alsaiari, Sachin Patil, Mram Alyami, Kholod O Alamoudi, Fajr A Aleisa, Jasmeen S Merzaban, Mo Li, and Niveen M Khashab. "Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework". ACS Publications.
  • Jonas G. Croissant, Xavier Cattoën, Michel Wong Chi Man, Jean-Olivier Durand and Niveen M. Khashab. "Syntheses and applications of periodic mesoporous organosilica nanoparticles". Nanoscale.
  • Jonas G Croissant, Dingyuan Zhang, Shahad Alsaiari, Jie Lu, Lin Deng, Fuyuhiko Tamanoi, Abdulaziz M AlMalik, Jeffrey I Zink, and Niveen M Khashab. "Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging". Journal of Controlled Release.
  • Mram Z Alyami, Shahad K Alsaiari, Yanyan Li, Somayah S Qutub, Fajr A Aleisa, Rachid Sougrat, Jasmeen S Merzaban, and Niveen M Khashab. "Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks". ACS Publications.

Awards

Niveen won the Great Arab Minds Award in Natural Sciences in 2023 for her contributions to chemistry, bioengineering, and biology.

References

  1. Niveen Khashab's page on King Abdullah University of Science and Technology's website
  2. "Her CV" (PDF). Archived from the original (PDF) on 2016-10-14. Retrieved 2016-10-13.
  3. Announcement of Laureates of 2017 L’Oréal-UNESCO For Women in Science Awards Archived 2016-10-10 at the Wayback Machine
  4. "Congratulations to the 2023 Cram Lehn Pedersen Prize Winner: Niveen Khashab – Chemical Communications Blog". Retrieved 2023-03-03.
  5. "Niveen Khashab". KAUST PORTAL FOR RESEARCHERS AND STUDENTS. Retrieved 2023-03-03.
  6. "A young researcher in the spotlight: Niveen M. Khashab - ISGS". 2019-03-29. Retrieved 2023-03-03.
  7. International, Drug Patents (2016-01-03). "One Organic Chemist One Day: Niveen M. Khashab". One Organic Chemist One Day. Retrieved 2023-03-03.
  8. Min Song, Hyon; H. Anjum, Dalaver; M. Khashab, Niveen (2012). "Shape-controlled synthesis of Au@Pd core-shell nanoparticles and their corresponding electrochemical properties". RSC Advances. 2 (9): 3621–3624. Bibcode:2012RSCAd...2.3621S. doi:10.1039/C2RA20152F.
  9. Li, Song; Li, Wengang; Khashab, Niveen M. (2012-12-01). "Stimuli responsive nanomaterials for controlled release applications". Nanotechnology Reviews. 1 (6): 493–513. doi:10.1515/ntrev-2012-0033. ISSN 2191-9097. S2CID 135482439.
  10. Huang, Guoyou; Li, Fei; Zhao, Xin; Ma, Yufei; Li, Yuhui; Lin, Min; Jin, Guorui; Lu, Tian Jian; Genin, Guy M.; Xu, Feng (2017-10-25). "Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment". Chemical Reviews. 117 (20): 12764–12850. doi:10.1021/acs.chemrev.7b00094. ISSN 0009-2665. PMC 6494624. PMID 28991456.
  11. Chand, Santanu; Alahmed, Othman; Baslyman, Walaa S.; Dey, Avishek; Qutub, Somayah; Saha, Ranajit; Hijikata, Yuh; Alaamery, Manal; Khashab, Niveen M. (2022-03-28). "DNA-Mimicking Metal–Organic Frameworks with Accessible Adenine Faces for Complementary Base Pairing". JACS Au. 2 (3): 623–630. doi:10.1021/jacsau.1c00516. ISSN 2691-3704. PMC 8969998. PMID 35373199.
  12. Alimi, Lukman O.; Fang, Fang; Moosa, Basem; Ding, Yanjun; Khashab, Niveen M. (2022-10-24). "Vapor-Triggered Mechanical Actuation in Polymer Composite Films Based on Crystalline Organic Cages". Angewandte Chemie International Edition. 61 (43): e202212596. doi:10.1002/anie.202212596. hdl:10754/680836. ISSN 1433-7851. PMID 36047488. S2CID 251978883.
  13. Huang, Tiefan; Moosa, Basem A.; Hoang, Phuong; Liu, Jiangtao; Chisca, Stefan; Zhang, Gengwu; AlYami, Mram; Khashab, Niveen M.; Nunes, Suzana P. (2020-11-18). "Molecularly-porous ultrathin membranes for highly selective organic solvent nanofiltration". Nature Communications. 11 (1): 5882. Bibcode:2020NatCo..11.5882H. doi:10.1038/s41467-020-19404-6. ISSN 2041-1723. PMC 7674481. PMID 33208753.
  14. Zhang, Gengwu; Hua, Bin; Dey, Avishek; Ghosh, Munmun; Moosa, Basem A.; Khashab, Niveen M. (2021-01-05). "Intrinsically Porous Molecular Materials (IPMs) for Natural Gas and Benzene Derivatives Separations". Accounts of Chemical Research. 54 (1): 155–168. doi:10.1021/acs.accounts.0c00582. ISSN 0001-4842. PMID 33332097. S2CID 229316181.
  15. O. Alimi, Lukman; Z. Alyami, Mram; Chand, Santanu; Baslyman, Walaa; M. Khashab, Niveen (2021). "Coordination-based self-assembled capsules (SACs) for protein, CRISPR–Cas9, DNA and RNA delivery". Chemical Science. 12 (7): 2329–2344. doi:10.1039/D0SC05975G. PMC 8179292. PMID 34163998.
  16. Alsaiari, Shahad K; Patil, Sachin; Alyami, Mram; Alamoudi, Kholod O; Aleisa, Fajr A; Merzaban, Jasmeen S; Li, Mo; Khashab, Niveen M (2018-01-01). "Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework". Journal of the American Chemical Society. 140 (1): 143–146. Bibcode:2018JAChS.140..143A. doi:10.1021/jacs.7b11754. hdl:10754/626437. ISSN 1520-5126. PMID 29272114.
  17. Carbon nanomaterials sourcebook. Volume 1, Graphene, fullerenes, nanotubes, and nanodiamonds. Klaus D. Sattler. Boca Raton, FL. 2016. ISBN 978-1-4822-5269-9. OCLC 945552732.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  18. US10807048B2, KHASHAB, Niveen M.; Chen, Ye & Tao, Jing, "Compositions of graphene materials with metal nanostructures and microstructures and methods of making and using including pressure sensors", issued 2020-10-20 
  19. US20180296469A1, Kosel, Jürgen; Khashab, Niveen & Zaher, Amir, "Magnetically controlled permeability membranes", issued 2018-10-18 
  20. EP3471864A1, HAMMAMI, Mohamed Amen; Francis, Lijo & CROISSANT, Jonas et al., "Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same", issued 2019-04-24 
  21. US20200046849A1, ALSAIARI, Shahad; HAMMAMI, Mohamed Amen & KHASHAB, Niveen M., "Nanocluster capped mesoporous nanoparticles, methods of making and use", issued 2020-02-13 
  22. US20160297952A1, Chen, Ye; Tao, Jing & Deng, Lin et al., "Polymer carbon nanotube composite", issued 2016-10-13 
  23. US9650494B2, Chen, Ye; Tao, Jing & Deng, Lin et al., "Polymer nanocomposites and methods of making nanocomposites", issued 2017-05-16 
  24. WO2021124219A1, ZHANG, Gengwu & KHASHAB, Niveen M., "Separating aromatic isomers using aqueous solutions of cucurbituril macrocycles", issued 2021-06-24 
  25. US20200306701A1, HAMMAMI, Mohamed Amen; FRANCIS, Lijo & CROISSANT, Jonas et al., "Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same", issued 2020-10-01 
  26. WO2021053409A1, KHASHAB, Niveen M. & HOANG, Phuong Mai, "Encoding raman spectral data in optical identification tags for analyte identification", issued 2021-03-25 
  27. Croissant, Jonas G.; Fatieiev, Yevhen; Khashab, Niveen M. (March 2017). "Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles". Advanced Materials. 29 (9): 1604634. Bibcode:2017AdM....2904634C. doi:10.1002/adma.201604634. PMID 28084658. S2CID 205274162.
  28. Croissant, Jonas G.; Fatieiev, Yevhen; Almalik, Abdulaziz; Khashab, Niveen M. (February 2018). "Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications". Advanced Healthcare Materials. 7 (4): 1700831. doi:10.1002/adhm.201700831. hdl:10754/626577. PMID 29193848. S2CID 3445633.
  29. Alsaiari, Shahad K.; Patil, Sachin; Alyami, Mram; Alamoudi, Kholod O.; Aleisa, Fajr A.; Merzaban, Jasmeen S.; Li, Mo; Khashab, Niveen M. (2018-01-10). "Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework". Journal of the American Chemical Society. 140 (1): 143–146. Bibcode:2018JAChS.140..143A. doi:10.1021/jacs.7b11754. hdl:10754/626437. ISSN 0002-7863. PMID 29272114.
  30. Croissant, Jonas G.; Cattoën, Xavier; Man, Michel Wong Chi; Durand, Jean-Olivier; Khashab, Niveen M. (2015-12-03). "Syntheses and applications of periodic mesoporous organosilica nanoparticles". Nanoscale. 7 (48): 20318–20334. Bibcode:2015Nanos...720318C. doi:10.1039/C5NR05649G. ISSN 2040-3372. PMID 26585498.
  31. Croissant, Jonas G.; Zhang, Dingyuan; Alsaiari, Shahad; Lu, Jie; Deng, Lin; Tamanoi, Fuyuhiko; AlMalik, Abdulaziz M.; Zink, Jeffrey I.; Khashab, Niveen M. (2016-05-10). "Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging". Journal of Controlled Release. 229: 183–191. doi:10.1016/j.jconrel.2016.03.030. hdl:10754/603622. ISSN 0168-3659. PMID 27016140.
  32. Alyami, Mram Z.; Alsaiari, Shahad K.; Li, Yanyan; Qutub, Somayah S.; Aleisa, Fajr A.; Sougrat, Rachid; Merzaban, Jasmeen S.; Khashab, Niveen M. (2020-01-29). "Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks". Journal of the American Chemical Society. 142 (4): 1715–1720. Bibcode:2020JAChS.142.1715A. doi:10.1021/jacs.9b11638. hdl:10754/678579. ISSN 0002-7863. PMID 31931564. S2CID 210194377.
  33. "Lebanese Prof. Niveen Khashab Wins Great Arab Minds Award in Natural Sciences". english.aawsat.com. Retrieved 2024-07-31.

External links

Categories: