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Non-specific polyamine oxidase (EC 1.5.3.17, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming). This enzyme catalyses the following chemical reaction

(1) spermine + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ spermidine + 3-aminopropanal + H₂O₂

(2) spermidine + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ putrescine + 3-aminopropanal + H₂O₂

(3) N-acetylspermine + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ spermidine + 3-acetamidopropanal + H₂O₂

(4) N-acetylspermidine + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ putrescine + 3-acetamidopropanal + H₂O₂

This enzyme is flavoprotein (FAD).

References

1. Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA (August 2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis". Plant Physiology. 147 (4): 1845–57. doi:10.1104/pp.108.123802. PMC 2492618. PMID 18583528.
2. Müller S, Walter RD (April 1992). "Purification and characterization of polyamine oxidase from Ascaris suum". The Biochemical Journal. 283 ( Pt 1): 75–80. PMC 1130995. PMID 1567380.
3. Landry J, Sternglanz R (April 2003). "Yeast Fms1 is a FAD-utilizing polyamine oxidase". Biochemical and Biophysical Research Communications. 303 (3): 771–6. doi:10.1016/s0006-291x(03)00416-9. PMID 12670477.

External links

• Non-specific+polyamine+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.5.3