Micrograph showing extreme nuclear atypia in cancer (glioblastoma ). Brain biopsy . HPS stain .Cytopathology of reactive urothelial changes, Pap stain , showing urothelial cells with enlarged nuclei but a nucleus-cytoplasm ratio of less than 0.5. There are bacteria, as well as an inflammatory response of neutrophils , providing a cause for the changes. Nuclear atypia refers to abnormal appearance of cell nuclei . It is a term used in cytopathology and histopathology . Atypical nuclei are often pleomorphic .
Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and malignancy . Severe nuclear atypia is, in most cases, considered an indicator of malignancy .
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