O'Toole is an Irish surname. It may refer to:
People
- O'Toole family, a leading family in Gaelic Leinster
- O'Toole (surname)
Other uses
- Erin O'Toole, (b. 1973) former leader of the Opposition of Canada and former leader of the Conservative Party of Canada
- Peter O'Toole (1932-2013), British actor
- Annette O'Toole (b. 1952) American actress, dancer, and singer-songwriter
- O'Tooles GAC football and hurling club in Dublin
- Ensign O'Toole, a military sitcom starring Dean Jones, which aired on NBC, 1962-1963
- Ensign O'Toole and Me, the title of a semi-autobiographical novel by William Lederer
- Kevin F. O'Toole (1950), American lawyer, attorney and gaming regulator
- Robert E. O'Toole, a.k.a "Slaps O'Toole", Former Boston Police Deputy Superintendent of Special Operations
- Kathleen M. O'Toole, former Chief of the Seattle Police Department, Commissioner of the Boston Police Department, Massachusetts Secretary of Public Safety and Chief Inspector of the Garda Síochána, the Irish national police service.
- Plenty O'Toole, James Bond girl
- Slugger O'Toole, Irish weblog
- St. Laurence O'Toole Pipe Band
- Sneakers O'Toole, Family Guy character from episode "Boys Do Cry"
- Timmy O'Toole Bart's fictional character who fell down a well in an episode of the Simpsons
- USS O'Toole, the name of more than one United States Navy ship
See also
- Other anglicizations of ó Tuathail:
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