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OSBPL1A

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Protein-coding gene in the species Homo sapiens
OSBPL1A
Identifiers
AliasesOSBPL1A, ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDsOMIM: 606730; MGI: 1927551; HomoloGene: 84746; GeneCards: OSBPL1A; OMA:OSBPL1A - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)
Chromosome 18 (human)Genomic location for OSBPL1AGenomic location for OSBPL1A
Band18q11.2Start24,162,045 bp
End24,397,880 bp
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)
Chromosome 18 (mouse)Genomic location for OSBPL1AGenomic location for OSBPL1A
Band18|18 A1Start12,888,371 bp
End13,074,898 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • internal globus pallidus

  • inferior ganglion of vagus nerve

  • postcentral gyrus

  • external globus pallidus

  • subthalamic nucleus

  • Pons

  • pars reticulata

  • lateral nuclear group of thalamus

  • Occipital Lobe
Top expressed in
  • prefrontal cortex

  • deep cerebellar nuclei

  • barrel cortex

  • medial geniculate nucleus

  • primary motor cortex

  • medial dorsal nucleus

  • pontine nuclei

  • lateral geniculate nucleus

  • medial vestibular nucleus

  • olfactory epithelium
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114876

64291

Ensembl

ENSG00000141447

ENSMUSG00000044252

UniProt

Q9BXW6

Q91XL9

RefSeq (mRNA)

NM_001242508
NM_018030
NM_080597
NM_133268

NM_001252489
NM_001252490
NM_001252491
NM_001252492
NM_001252493

NM_020573
NM_207530

RefSeq (protein)

NP_001229437
NP_060500
NP_542164

NP_001239418
NP_001239419
NP_001239420
NP_001239421
NP_001239422

NP_997413

Location (UCSC)Chr 18: 24.16 – 24.4 MbChr 18: 12.89 – 13.07 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000141447Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000044252Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi:10.1074/jbc.M101204200. PMID 11279184.
  6. Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.
  7. ^ "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

Further reading


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