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OSBPL3

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Protein-coding gene in the species Homo sapiens

OSBPL3
Identifiers
AliasesOSBPL3, ORP-3, ORP3, OSBP3, oxysterol binding protein like 3
External IDsOMIM: 606732; MGI: 1918970; HomoloGene: 49422; GeneCards: OSBPL3; OMA:OSBPL3 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)
Chromosome 7 (human)Genomic location for OSBPL3Genomic location for OSBPL3
Band7p15.3Start24,796,540 bp
End24,981,634 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for OSBPL3Genomic location for OSBPL3
Band6|6 B2.3Start50,270,310 bp
End50,433,181 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • amniotic fluid

  • oocyte

  • secondary oocyte

  • left lobe of thyroid gland

  • gonad

  • right lobe of thyroid gland

  • stromal cell of endometrium

  • mucosa of paranasal sinus

  • skin of abdomen
Top expressed in
  • transitional epithelium of urinary bladder

  • lumbar spinal ganglion

  • epithelium of stomach

  • proximal tubule

  • right kidney

  • human kidney

  • otolith organ

  • utricle

  • ascending aorta

  • adrenal gland
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26031

71720

Ensembl

ENSG00000070882

ENSMUSG00000029822

UniProt

Q9H4L5

Q9DBS9

RefSeq (mRNA)
NM_015550
NM_145320
NM_145321
NM_145322
NM_145323

NM_145324

NM_001163645
NM_027881
NM_001347213

RefSeq (protein)

NP_056365
NP_663160
NP_663161
NP_663162

NP_001157117
NP_001334142
NP_082157

Location (UCSC)Chr 7: 24.8 – 24.98 MbChr 6: 50.27 – 50.43 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000070882Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029822Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ "Entrez Gene: OSBPL3 oxysterol binding protein-like 3".

Further reading


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