Odom is a surname originating from England. Notable people with the surname include:
- Andrew Odom (1936–1991), American blues singer and songwriter
- Antwan Odom (born 1981), American football player
- Barry Odom (born 1976), American football coach
- Bob Odom (1935–2014), former Louisiana Commissioner of Agriculture and Forestry
- Brian Odom (born 1981), American football coach
- Carmen Hooker Odom, former state government agency head
- Christopher C. Odom (born 1970), movie director
- Chris Odom (born 1994), American football player
- Cliff Odom (born 1958), American football player
- Dave Odom (born 1942), American basketball coach
- Duncan Odom, cancer genetics researcher at the University of Cambridge
- Elzie Odom (born 1929), American politician
- Frederick M. Odom (c. 1871–1960), Justice of the Louisiana Supreme Court
- Gary Odom, Tennessee politician
- George Odom (disambiguation)
- Heinie Odom (1900–1970), American baseball player
- Jason Odom (born 1974), American football player
- Joe Odom (attorney) (1948–1991), American attorney-turned-musician
- Joe Odom (born 1979), American football player
- John C. Odom (1982-2008), American baseball player
- Johnny Lee "Blue Moon" Odom (born 1945), American baseball player
- Joseph Odom (born 1992), American professional baseball catcher
- Lamar Odom (born 1979), American basketball player
- Leslie Odom Jr. (born 1981), American actor and singer
- Lometa Odom (1933–2017), American basketball player and coach
- Mary H. Odom (1921–2014), American politician and educator
- Mel Odom (disambiguation)
- Sammy Joe Odom, American football player
- Steve Odom (born 1952), American football player
- Susan Odom (1980-2021), American chemistry professor
- Tyler Odom, rock guitarist
- Vernon Odom, Sr. (1921–1996), American civil rights leader
- Vernon Odom (born 1948), American journalist
- William Odom (1932–2008), former director of the U.S. National Security Agency
See also
- Odom's indicator, a piece of anesthetic equipment
- Odum (disambiguation)
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