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OmpA family
crystal structure of tolb/pal complex
Identifiers
Symbol	OmpA
Pfam	PF00691
InterPro	IPR006665
PROSITE	PDOC00819
SCOP2	1r1m / SCOPe / SUPFAM
TCDB	1.B.6
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the OmpA domain is a conserved protein domain with a beta/alpha/beta/alpha-beta(2) structure found in the C-terminal region of many Gram-negative bacterial outer membrane proteins, such as porin-like integral membrane proteins (such as ompA), small lipid-anchored proteins (such as pal), and MotB proton channels. The N-terminal half of these proteins is variable although some of the proteins in this group have the OmpA-like transmembrane domain at the N terminus. OmpA from Escherichia coli is required for pathogenesis, and can interact with host receptor molecules. MotB (and MotA) serve two functions in E. coli, the MotA(4)-MotB(2) complex attaches to the cell wall via MotB to form the stator of the flagellar motor, and the MotA-MotB complex couples the flow of ions across the cell membrane to movement of the rotor.

See also

• OmpA-like transmembrane domain

References

1. Bouveret E, Benedetti H, Rigal A, Loret E, Lazdunski C (October 1999). "In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions". J. Bacteriol. 181 (20): 6306–11. doi:10.1128/JB.181.20.6306-6311.1999. PMC 103764. PMID 10515919.
2. De Mot R, Proost P, Van Damme J, Vanderleyden J (February 1992). "Homology of the root adhesin of Pseudomonas fluorescens OE 28.3 with porin F of P. aeruginosa and P. syringae". Mol. Gen. Genet. 231 (3): 489–93. doi:10.1007/BF00292721. PMID 1538702. S2CID 7518948.
3. Freudl R, Klose M, Henning U (June 1990). "Export and sorting of the Escherichia coli outer membrane protein OmpA". J. Bioenerg. Biomembr. 22 (3): 441–9. doi:10.1007/BF00763176. PMID 2202726. S2CID 22623025.
4. ^ Hosking ER, Vogt C, Bakker EP, Manson MD (December 2006). "The Escherichia coli MotAB proton channel unplugged". J. Mol. Biol. 364 (5): 921–37. doi:10.1016/j.jmb.2006.09.035. PMID 17052729.
5. Selvaraj SK, Periandythevar P, Prasadarao NV (April 2007). "Outer membrane protein A of Escherichia coli K1 selectively enhances the expression of intercellular adhesion molecule-1 in brain microvascular endothelial cells". Microbes Infect. 9 (5): 547–57. doi:10.1016/j.micinf.2007.01.020. PMC 1993839. PMID 17368067.

• Protein families
• Outer membrane proteins