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In enzymology, an orotate reductase (NADH) (EC 1.3.1.14) is an enzyme that catalyzes the chemical reaction

(S)-dihydroorotate + NAD ${\displaystyle \rightleftharpoons }$ orotate + NADH + H

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NAD, whereas its 3 products are orotate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NAD+ oxidoreductase. This enzyme is also called orotate reductase (NADH). This enzyme participates in pyrimidine metabolism. It has 2 cofactors: FAD, and FMN.

References

• FRIEDMANN HC, VENNESLAND B (1958). "Purification and properties of dihydro-orotic dehydrogenase". J. Biol. Chem. 233 (6): 1398–406. PMID 13610849.
• FRIEDMANN HC, VENNESLAND B (1960). "Crystalline dihydroorotic dehydrogenase". J. Biol. Chem. 235: 1526–32. PMID 13825167.
• LIEBERMAN I, KORNBERG A (1953). "Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I Dihydro-orotic dehydrogenase". Biochim. Biophys. Acta. 12 (1–2): 223–34. doi:10.1016/0006-3002(53)90141-3. PMID 13115431.

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