Ortuño or Ortuno may refer to:
- Teresa Ortuño Gurza (born 1957), Mexican politician and senator
- Alfredo Ortuño (born 1991), Spanish professional footballer
- Alicia Ortuño (born 1976), professional tennis player from Spain
- Antonio Ortuño (born 1976), Mexican novelist and short story writer
- Catalino Duarte Ortuño (born 1970), Mexican politician
- Fernando Ortuño (1945–2015), Spanish footballer
- Isabel Ortuño (born 1982), Spanish handballer
- Jesús Rodríguez Ortuño (born 1998), AKA Echu, Spanish footballer
- Juanto Ortuño (born 1992), AKA Juanto, is a Spanish footballer
- Maria de los Angeles Rozalen Ortuno (born 1986), Spanish singer and songwriter
- Rene Barrientos Ortuno (1919–1969), Bolivian military officer, 47th president of Bolivia
- Sergio Ortuño (born 1999), Spanish professional footballer
- Valeria Ortuño (born 1998), Mexican racewalker
- Washington Ortuño (1928–1973), Uruguayan footballer
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