Ostroumov (Russian: Остроумов; from ostryi um, meaning sharp intellect) is a Russian masculine surname, its feminine counterpart is Ostroumova. The surname may refer to the following notable people:
- Alexander Ostroumov (1859–1920), Russian pharmaceutical chemist, perfume and cosmetics maker.
- Anna Ostroumova-Lebedeva (1871—1955), Russian artist
- Nikolai Ostroumov (1846–1930), Russian educationalist in Turkestan
- Olga Ostroumova (born 1947), Russian theater and film actress
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