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In enzymology, an oxalate—CoA ligase (EC 6.2.1.8) is an enzyme that catalyzes the chemical reaction

ATP + oxalate + CoA ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + oxalyl-CoA

The 3 substrates of this enzyme are ATP, oxalate, and coenzyme A (CoA), whereas its 3 products are AMP, diphosphate, and oxalyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is oxalate:CoA ligase (AMP-forming). Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Organisms with Oxalate-CoA Ligases include:
Arabidopsis thaliana
Saccharomyces cerevisiae

References

1. "A Previously Unknown Oxalyl-CoA Synthetase Is Important for Oxalate Catabolism in Arabidopsis". www.plantcell.org. Archived from the original on 24 September 2015. Retrieved 17 September 2023.
2. Foster J, Nakata PA (2014). "An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae". FEBS Lett. 588 (1): 160–6. doi:10.1016/j.febslet.2013.11.026. PMID 24291261.

• Giovanelli J (1966). "Oxalyl-coenzyme A synthetase from pea seeds". Biochim. Biophys. Acta. 118 (1): 124–43. doi:10.1016/s0926-6593(66)80151-0. PMID 4288975.

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