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Oxepanoprolinamide

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Class of chemical compounds
Chemical structure of iboxamycin

Oxepanoprolinamides are a class of antibiotics. They include iboxamycin. These drugs are fully synthetic. The molecules contain the aminooctose component of clindamycin. They were developed by Andrew G. Myers and Yury S. Polikanov. The structure contains an oxepane (a seven-membered ring compound with oxygen) and a proline, with an amide group that increases rigidity.

Oxepanoprolinamides function by insertion into bacterial ribosomes. They overcome a type of antibiotic resistance to clindamycin based on Erm and Cfr ribosomal RNA methyltransferase enzymes.

References

  1. ^ Halford, Bethany (28 October 2021). "New class of synthetic antibiotics battle drug-resistant bacteria". Chemical & Engineering News. 99 (40). Archived from the original on 29 October 2021. Retrieved 3 November 2021.
  2. Mitcheltree, Matthew J.; Pisipati, Amarnath; Syroegin, Egor A.; Silvestre, Katherine J.; Klepacki, Dorota; Mason, Jeremy D.; Terwilliger, Daniel W.; Testolin, Giambattista; Pote, Aditya R.; Wu, Kelvin J. Y.; Ladley, Richard Porter; Chatman, Kelly; Mankin, Alexander S.; Polikanov, Yury S.; Myers, Andrew G. (2021). "A synthetic antibiotic class overcoming bacterial multidrug resistance". Nature. 599 (7885): 507–599. Bibcode:2021Natur.599..507M. doi:10.1038/s41586-021-04045-6. PMC 8549432. PMID 34707295.
  3. Mitcheltree, Matthew J.; Pisipati, Amarnath; Syroegin, Egor A.; Silvestre, Katherine J.; Klepacki, Dorota; Mason, Jeremy D.; Terwilliger, Daniel W.; Testolin, Giambattista; Pote, Aditya R.; Wu, Kelvin J. Y.; Ladley, Richard Porter; Chatman, Kelly; Mankin, Alexander S.; Polikanov, Yury S.; Myers, Andrew G. (27 October 2021). "A synthetic antibiotic class overcoming bacterial multidrug resistance". Nature. 599 (7885): 507–512. Bibcode:2021Natur.599..507M. doi:10.1038/s41586-021-04045-6. PMC 8549432. PMID 34707295.
  4. "Bacterial drug resistance overcome by synthetic restructuring of antibiotics". Nature: d41586–021–02916-6. 27 October 2021. doi:10.1038/d41586-021-02916-6. PMID 34711985. S2CID 240153291.
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