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P2RY1

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(Redirected from P2Y1) Protein-coding gene in the species Homo sapiens

P2RY1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4XNV, 4XNW

Identifiers
AliasesP2RY1, P2Y1, purinergic receptor P2Y1, SARCC
External IDsOMIM: 601167; MGI: 105049; HomoloGene: 1926; GeneCards: P2RY1; OMA:P2RY1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for P2RY1Genomic location for P2RY1
Band3q25.2Start152,835,131 bp
End152,841,439 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for P2RY1Genomic location for P2RY1
Band3|3 E1Start60,910,216 bp
End60,916,403 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • endothelial cell

  • oral cavity

  • internal globus pallidus

  • visceral pleura

  • amniotic fluid

  • placenta

  • nucleus accumbens

  • tibia

  • lower lobe of lung
Top expressed in
  • lumbar spinal ganglion

  • duodenum

  • islet of Langerhans

  • granulocyte

  • jejunum

  • esophagus

  • lip

  • muscle of thigh

  • embryo

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5028

18441

Ensembl

ENSG00000169860

ENSMUSG00000027765

UniProt

P47900

P49650

RefSeq (mRNA)

NM_002563

NM_001282016
NM_008772

RefSeq (protein)

NP_002554

NP_001268945
NP_032798

Location (UCSC)Chr 3: 152.84 – 152.84 MbChr 3: 60.91 – 60.92 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.

Function

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000169860Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027765Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.
  6. "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".

Further reading

External links

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors
Class A: Rhodopsin-like
Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Class B: Secretin-like
Adhesion
Orphan
Other
Class C: Metabotropic glutamate / pheromone
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened
Purine receptor modulators
Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
See also: Receptor/signaling modulators
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