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PAFAH2
Identifiers
Aliases	PAFAH2, HSD-PLA2, platelet activating factor acetylhydrolase 2
External IDs	OMIM: 602344; MGI: 2140321; HomoloGene: 37309; GeneCards: PAFAH2; OMA:PAFAH2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.11 Start 25,959,767 bp End 25,998,117 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.3 Start 134,123,631 bp End 134,154,724 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas epithelium of colon granulocyte islet of Langerhans rectum thymus mucosa of transverse colon gastrocnemius muscle gonad muscle of thigh Top expressed in left lobe of liver epithelium of stomach human kidney migratory enteric neural crest cell lacrimal gland right kidney proximal tubule Paneth cell transitional epithelium of urinary bladder Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipid binding hydrolase activity 1-alkyl-2-acetylglycerophosphocholine esterase activity Cellular component cytoplasm endoplasmic reticulum endoplasmic reticulum membrane membrane Biological process lipid catabolic process negative regulation of apoptotic process lipid metabolism blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5051 100163 Ensembl ENSG00000158006 ENSMUSG00000037366 UniProt Q99487 Q5SY00 Q8VDG7 RefSeq (mRNA) NM_000437 NM_001285872 NM_001285874 NM_001285875 NM_001285877 NM_133880 RefSeq (protein) NP_000428 NP_001272801 NP_001272803 NP_001272804 NP_001272806 NP_598641 Location (UCSC) Chr 1: 25.96 – 26 Mb Chr 4: 134.12 – 134.15 Mb PubMed search
Wikidata
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Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene. It is one of several PAF acetylhydrolases.

Function

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000158006 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000037366 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hattori K, Adachi H, Matsuzawa A, Yamamoto K, Tsujimoto M, Aoki J, Hattori M, Arai H, Inoue K (Dec 1996). "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase". The Journal of Biological Chemistry. 271 (51): 33032–8. doi:10.1074/jbc.271.51.33032. PMID 8955149.
6. Rice SQ, Southan C, Boyd HF, Terrett JA, MacPhee CH, Moores K, Gloger IS, Tew DG (Mar 1998). "Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor". The Biochemical Journal. 330 ( Pt 3) (3): 1309–15. doi:10.1042/bj3301309. PMC 1219277. PMID 9494101.
7. ^ "Entrez Gene: PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa".

Further reading

• Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM (Jul 1997). "Platelet-activating factor acetylhydrolases". The Journal of Biological Chemistry. 272 (29): 17895–8. doi:10.1074/jbc.272.29.17895. PMID 9218411.
• Umemura K, Kato I, Hirashima Y, Ishii Y, Inoue T, Aoki J, Kono N, Oya T, Hayashi N, Hamada H, Endo S, Oda M, Arai H, Kinouchi H, Hiraga K (Mar 2007). "Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia". Stroke: A Journal of Cerebral Circulation. 38 (3): 1063–8. doi:10.1161/01.STR.0000257981.09329.d2. PMID 17272759.
• Schmidt EB, Koenig W, Khuseyinova N, Christensen JH (Jan 2008). "Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids". Atherosclerosis. 196 (1): 420–4. doi:10.1016/j.atherosclerosis.2006.11.027. PMID 17157859.
• Unno N, Sakaguchi T, Nakamura T, Yamamoto N, Sugatani J, Miwa M, Konno H (Jul 2006). "A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease". The Journal of Surgical Research. 134 (1): 36–43. doi:10.1016/j.jss.2006.02.058. PMID 16650870.
• Marques M, Pei Y, Southall MD, Johnston JM, Arai H, Aoki J, Inoue T, Seltmann H, Zouboulis CC, Travers JB (Oct 2002). "Identification of platelet-activating factor acetylhydrolase II in human skin". The Journal of Investigative Dermatology. 119 (4): 913–9. doi:10.1046/j.1523-1747.2002.01859.x. PMID 12406338.
• Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH (Apr 2001). "Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme" (PDF). Biochemistry. 40 (15): 4539–49. doi:10.1021/bi002600g. PMID 11294621.

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