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PASD1
Identifiers
Aliases	PASD1, CT63, OXTES1, PAS domain containing 1, PAS domain containing repressor 1, CT64
External IDs	OMIM: 300993; HomoloGene: 131196; GeneCards: PASD1; OMA:PASD1 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 151,563,675 bp End 151,676,739 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis gonad human musculoskeletal system muscular system muscle skeletal muscle lower limb muscles muscle of leg n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator binding Cellular component Cry-Per complex nucleus nuclear speck Biological process negative regulation of circadian rhythm negative regulation of transcription, DNA-templated rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 139135 n/a Ensembl ENSG00000166049 n/a UniProt Q8IV76 n/a RefSeq (mRNA) NM_173493 n/a RefSeq (protein) NP_775764 n/a Location (UCSC) Chr X: 151.56 – 151.68 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene.

PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000166049 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". International Journal of Cancer. 110 (4): 563–569. doi:10.1002/ijc.20170. PMID 15122589.
4. Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". British Journal of Cancer. 91 (1): 141–149. doi:10.1038/sj.bjc.6601875. PMC 2364759. PMID 15162151.
5. "Entrez Gene: PASD1 PAS domain containing 1".
6. Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC 4458219. PMID 25936801.
7. Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine.

Further reading

• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, et al. (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications. 335 (4): 1293–1304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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