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PDE7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKL, 3G3N, 4PM0, 4Y2B
Identifiers
Aliases	PDE7A, HCP1, PDE7, phosphodiesterase 7A
External IDs	OMIM: 171885; MGI: 1202402; HomoloGene: 1956; GeneCards: PDE7A; OMA:PDE7A - orthologs
EC number	3.1.4.53
Gene location (Human) Chr. Chromosome 8 (human) Band 8q13.1 Start 65,714,334 bp End 65,842,322 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 A2|3 5.36 cM Start 19,277,272 bp End 19,365,486 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte thymus Skeletal muscle tissue of rectus abdominis apex of heart muscle of thigh lymph node gastrocnemius muscle deltoid muscle appendix right auricle Top expressed in left lung lobe spermatocyte Rostral migratory stream conjunctival fornix left colon ganglionic eminence primitive streak spermatid muscle of thigh mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity metal ion binding phosphoric diester hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity Cellular component cytosol cytoplasm Biological process cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5150 18583 Ensembl ENSG00000205268 ENSMUSG00000069094 UniProt Q13946 P70453 RefSeq (mRNA) NM_001242318 NM_002603 NM_002604 NM_001122759 NM_008802 RefSeq (protein) NP_001229247 NP_002594 NP_001116231 NP_032828 Location (UCSC) Chr 8: 65.71 – 65.84 Mb Chr 3: 19.28 – 19.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene. Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

References

1. ^ GRCh38: Ensembl release 89: ENSG00000205268 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000069094 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. doi:10.1016/S0021-9258(18)31474-1. PMID 8389765.
6. Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
7. "Entrez Gene: PDE7A phosphodiesterase 7A".

Further reading

• Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. S2CID 19182571.
• Han P, Zhu X, Michaeli T (1997). "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart". J. Biol. Chem. 272 (26): 16152–7. doi:10.1074/jbc.272.26.16152. PMID 9195912.
• Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044.
• Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P (2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)". Biochem. Biophys. Res. Commun. 274 (2): 415–21. doi:10.1006/bbrc.2000.3146. PMID 10913353.
• Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
• Glavas NA, Ostenson C, Schaefer JB, Vasta V, Beavo JA (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. Bibcode:2001PNAS...98.6319G. doi:10.1073/pnas.101131098. PMC 33466. PMID 11371644.
• Lee R, Wolda S, Moon E, Esselstyn J, Hertel C, Lerner A (2002). "PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP". Cell. Signal. 14 (3): 277–84. doi:10.1016/S0898-6568(01)00250-9. PMID 11812656.
• Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, Kikkawa H, Omori K, Kaminuma O (2002). "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors". Clin. Exp. Immunol. 128 (3): 460–6. doi:10.1046/j.1365-2249.2002.01856.x. PMC 1906253. PMID 12067300.
• Smith SJ, Brookes-Fazakerley S, Donnelly LE, Barnes PJ, Barnette MS, Giembycz MA (2003). "Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (2): L279–89. doi:10.1152/ajplung.00170.2002. PMID 12388353.
• Torras-Llort M, Azorín F (2003). "Functional characterization of the human phosphodiesterase 7A1 promoter". Biochem. J. 373 (Pt 3): 835–43. doi:10.1042/BJ20021829. PMC 1223549. PMID 12737631.
• Wang H, Liu Y, Chen Y, Robinson H, Ke H (2005). "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7". J. Biol. Chem. 280 (35): 30949–55. doi:10.1074/jbc.M504398200. PMID 15994308.
• Sánchez AI, Meneses R, Mínguez JM, Núñez A, Castillo RR, Filace F, Burgos C, Vaquero JJ, Álvarez-Builla J, Cortés-Cabrera A, Gago F, Terricabras E, Segarra V (2014). "Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold". Org. Biomol. Chem. 12 (24): 4233–42. doi:10.1039/c4ob00175c. PMID 24838636.

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