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Phorbol-diester hydrolase

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phorbol-diester hydrolase
Identifiers
EC no.3.1.1.51
CAS no.81181-74-0
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The enzyme phorbol-diester hydrolase (EC 3.1.1.51) catalyzes the reaction

phorbol 12,13-dibutanoate + H2O {\displaystyle \rightleftharpoons } phorbol 13-butanoate + butanoate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is 12,13-diacylphorbate 12-acylhydrolase. Other names in common use include diacylphorbate 12-hydrolase, diacylphorbate 12-hydrolase, phorbol-12,13-diester 12-ester hydrolase, and PDEH.

References

  • Shoyab M, Warren TC, Todaro GJ (1981). "Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver". J. Biol. Chem. 256 (23): 12529–34. PMID 6946062.
Hydrolase: esterases (EC 3.1)
3.1.1: Carboxylic
ester hydrolases
3.1.2: Thioesterase
3.1.3: Phosphatase
3.1.4:
Phosphodiesterase
3.1.6: Sulfatase
Nuclease (includes
deoxyribonuclease
and ribonuclease)
3.1.11-16:
Exonuclease
Exodeoxyribonuclease
Exoribonuclease
3.1.21-31:
Endonuclease
Endodeoxyribonuclease
Endoribonuclease
either deoxy- or ribo-    
Enzymes
Activity
Regulation
Classification
Kinetics
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