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PDF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3G5K, 3G5P
Identifiers
Aliases	PDF, peptide deformylase (mitochondrial), peptide deformylase, mitochondrial
External IDs	MGI: 1915273; HomoloGene: 69354; GeneCards: PDF; OMA:PDF - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 69,326,913 bp End 69,330,588 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 107,771,330 bp End 107,775,246 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad human kidney right lobe of liver stromal cell of endometrium gastrocnemius muscle mucosa of transverse colon muscle of thigh skeletal muscle tissue right adrenal gland Top expressed in quadriceps femoris muscle proximal tubule right kidney muscle tissue skeletal muscle tissue muscle of thigh heart adrenal gland embryo liver More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity metal ion binding peptide deformylase activity Cellular component mitochondrion Biological process peptidyl-methionine modification N-terminal protein amino acid modification protein biosynthesis positive regulation of cell population proliferation co-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64146 68023 Ensembl ENSG00000258429 ENSMUSG00000078931 UniProt Q9HBH1 S4R2K0 RefSeq (mRNA) NM_022341 NM_026513 RefSeq (protein) NP_071736 NP_080789 Location (UCSC) Chr 16: 69.33 – 69.33 Mb Chr 8: 107.77 – 107.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Peptide deformylase, mitochondrial is an enzyme that in humans is encoded by the PDF gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000258429 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000078931 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Giglione C, Serero A, Pierre M, Boisson B, Meinnel T (Nov 2000). "Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms". EMBO J. 19 (21): 5916–29. doi:10.1093/emboj/19.21.5916. PMC 305796. PMID 11060042.
6. Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA (Oct 2004). "Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics". J Clin Invest. 114 (8): 1107–16. doi:10.1172/JCI22269. PMC 522256. PMID 15489958.
7. "Entrez Gene: PDF peptide deformylase (mitochondrial)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lee MD, Antczak C, Li Y, et al. (2004). "A new human peptide deformylase inhibitable by actinonin". Biochem. Biophys. Res. Commun. 312 (2): 309–15. doi:10.1016/j.bbrc.2003.10.123. PMID 14637138.
• Serero A, Giglione C, Sardini A, et al. (2004). "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway". J. Biol. Chem. 278 (52): 52953–63. doi:10.1074/jbc.M309770200. PMID 14532271.
• Nguyen KT, Hu X, Colton C, et al. (2003). "Characterization of a human peptide deformylase: implications for antibacterial drug design". Biochemistry. 42 (33): 9952–8. doi:10.1021/bi0346446. PMID 12924944.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9HBH1 (Human Peptide deformylase, mitochondrial) at the PDBe-KB.

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