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PELI1
Identifiers
Aliases	PELI1, pellino E3 ubiquitin protein ligase 1
External IDs	OMIM: 614797; MGI: 1914495; HomoloGene: 23243; GeneCards: PELI1; OMA:PELI1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p14 Start 64,092,652 bp End 64,144,420 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A3.1|11 13.81 cM Start 21,041,291 bp End 21,100,323 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus cartilage tissue mucosa of pharynx amniotic fluid skin of thigh vena cava oral cavity human penis bone marrow epithelium of nasopharynx Top expressed in medial ganglionic eminence blood mesenteric lymph nodes left lung lobe transitional epithelium of urinary bladder nucleus accumbens skin of external ear olfactory tubercle Rostral migratory stream anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding ubiquitin-ubiquitin ligase activity protein serine/threonine kinase activity transferase activity ubiquitin protein ligase activity Cellular component cytosol nucleus Biological process response to dsRNA positive regulation of toll-like receptor 3 signaling pathway positive regulation of cytokine production protein polyubiquitination negative regulation of T cell proliferation response to lipopolysaccharide positive regulation of B cell proliferation protein ubiquitination positive regulation of toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of B cell activation negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination negative regulation of T cell activation protein phosphorylation immune response Toll signaling pathway protein K48-linked ubiquitination interleukin-1-mediated signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of necroptotic process protein K63-linked ubiquitination regulation of Toll signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57162 67245 Ensembl ENSG00000197329 ENSMUSG00000020134 UniProt Q96FA3 Q8C669 RefSeq (mRNA) NM_020651 NM_023324 RefSeq (protein) NP_065702 NP_075813 Location (UCSC) Chr 2: 64.09 – 64.14 Mb Chr 11: 21.04 – 21.1 Mb PubMed search
Wikidata
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Protein pellino homolog 1 is a protein that in humans is encoded by the PELI1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000197329 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000020134 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–174. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.
6. Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH (Sep 2006). "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1". Nat Immunol. 7 (10): 1057–1065. doi:10.1038/ni1383. PMID 16951688. S2CID 9646386.
7. "Entrez Gene: PELI1 pellino homolog 1 (Drosophila)".

Further reading

• Rich T, Allen RL, Lucas AM, et al. (2001). "Pellino-related sequences from Caenorhabditis elegans and Homo sapiens". Immunogenetics. 52 (1–2): 145–149. doi:10.1007/s002510000249. PMID 11132151. S2CID 13467302.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiang Z, Johnson HJ, Nie H, et al. (2003). "Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex". J. Biol. Chem. 278 (13): 10952–10956. doi:10.1074/jbc.M212112200. PMID 12496252.
• Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2–3): 199–202. doi:10.1016/S0014-5793(03)00533-7. PMID 12804775. S2CID 46719284.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Butler MP, Hanly JA, Moynagh PN (2005). "Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner" (PDF). J. Biol. Chem. 280 (30): 27759–27768. doi:10.1074/jbc.M500756200. PMID 15917247. S2CID 30374239.
• Butler MP, Hanly JA, Moynagh PN (2007). "Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases". J. Biol. Chem. 282 (41): 29729–29737. doi:10.1074/jbc.M704558200. PMID 17675297.

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