Misplaced Pages

PEX26
Identifiers
Aliases	PEX26, PBD7A, PBD7B, PEX26M1T, Pex26pM1T, peroxisomal biogenesis factor 26
External IDs	OMIM: 608666; MGI: 1921293; HomoloGene: 9922; GeneCards: PEX26; OMA:PEX26 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.21 Start 18,077,923 bp End 18,105,396 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F1 Start 121,160,626 bp End 121,175,796 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon tendon of biceps brachii islet of Langerhans prefrontal cortex rectum ganglionic eminence stromal cell of endometrium anterior cingulate cortex duodenum ventricular zone Top expressed in secondary oocyte Paneth cell primary oocyte lacrimal gland left lung lobe medullary collecting duct hair follicle left lobe of liver otic vesicle transitional epithelium of urinary bladder More reference expression data BioGPS n/a
Gene ontology Molecular function ATPase binding protein C-terminus binding protein binding protein-containing complex binding Cellular component integral component of membrane peroxisome membrane integral component of peroxisomal membrane peroxisomal membrane Biological process protein transport protein import into peroxisome matrix protein import into peroxisome membrane protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55670 74043 Ensembl ENSG00000215193 ENSMUSG00000067825 UniProt Q7Z412 Q8BGI5 RefSeq (mRNA) NM_017929 NM_001127649 NM_001199319 NM_028730 NM_001304773 NM_001304774 RefSeq (protein) NP_001121121 NP_001186248 NP_060399 NP_001121121.1 NP_060399.1 NP_001291702 NP_001291703 NP_083006 Location (UCSC) Chr 22: 18.08 – 18.11 Mb Chr 6: 121.16 – 121.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.

Interactions

PEX26 has been shown to interact with PEX1, PEX6 and SUFU.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000215193 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000067825 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Matsumoto N, Tamura S, Fujiki Y (May 2003). "The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes". Nature Cell Biology. 5 (5): 454–60. doi:10.1038/ncb982. PMID 12717447. S2CID 2426040.
6. Matsumoto N, Tamura S, Furuki S, Miyata N, Moser A, Shimozawa N, Moser HW, Suzuki Y, Kondo N, Fujiki Y (Aug 2003). "Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation". American Journal of Human Genetics. 73 (2): 233–46. doi:10.1086/377004. PMC 1180364. PMID 12851857.
7. "Entrez Gene: PEX26 peroxisome biogenesis factor 26".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (Mar 2005). "Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis". Journal of Molecular Biology. 346 (5): 1275–86. doi:10.1016/j.jmb.2005.01.013. PMID 15713480.
• Weller S, Cajigas I, Morrell J, Obie C, Steel G, Gould SJ, Valle D (Jun 2005). "Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis". American Journal of Human Genetics. 76 (6): 987–1007. doi:10.1086/430637. PMC 1196456. PMID 15858711.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Furuki S, Tamura S, Matsumoto N, Miyata N, Moser A, Moser HW, Fujiki Y (Jan 2006). "Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex". The Journal of Biological Chemistry. 281 (3): 1317–23. doi:10.1074/jbc.M510044200. PMID 16257970.
• Halbach A, Landgraf C, Lorenzen S, Rosenkranz K, Volkmer-Engert R, Erdmann R, Rottensteiner H (Jun 2006). "Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites". Journal of Cell Science. 119 (Pt 12): 2508–17. doi:10.1242/jcs.02979. PMID 16763195. S2CID 20304149.
• Tamura S, Yasutake S, Matsumoto N, Fujiki Y (Sep 2006). "Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p". The Journal of Biological Chemistry. 281 (38): 27693–704. doi:10.1074/jbc.M605159200. PMID 16854980.

External links

• GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
• OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum

This protein-related article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 22
• Protein stubs