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PHLDB1
Identifiers
Aliases	PHLDB1, LL5A, pleckstrin homology like domain family B member 1
External IDs	OMIM: 612834; MGI: 2143230; HomoloGene: 15903; GeneCards: PHLDB1; OMA:PHLDB1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 118,606,440 bp End 118,658,031 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 44,686,304 bp End 44,735,198 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve middle frontal gyrus C1 segment apex of heart gastric mucosa left uterine tube canal of the cervix corpus callosum body of uterus right auricle Top expressed in saccule otic vesicle Rostral migratory stream ankle joint motor neuron otic placode molar external carotid artery calvaria lip More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23187 102693 Ensembl ENSG00000019144 ENSMUSG00000048537 UniProt Q86UU1 Q6PDH0 RefSeq (mRNA) NM_001144758 NM_001144759 NM_015157 NM_153537 RefSeq (protein) NP_001138230 NP_001138231 NP_055972 NP_001138231.1 NP_705765 Location (UCSC) Chr 11: 118.61 – 118.66 Mb Chr 9: 44.69 – 44.74 Mb PubMed search
Wikidata
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Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene.

The first PHLDB1 cDNA was cloned from a rat pituitary cDNA library and named as LL5 after the clone number.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000019144 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000048537 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (Oct 2003). "Identification and characterization of human LL5A gene and mouse Ll5a gene in silico". Int J Oncol. 23 (5): 1477–83. doi:10.3892/ijo.23.5.1477. PMID 14532993.
6. "Entrez Gene: PHLDB1 pleckstrin homology-like domain, family B, member 1".
7. Levi L, Hanukoglu I, Raikhinstein M, Kohen F, Koch Y (16 November 1993). "Cloning of LL5, a novel protein encoding cDNA from a rat pituitary library". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (2): 342–4. doi:10.1016/0167-4781(93)90171-9. PMID 8241284.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
• Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.

• Genes on human chromosome 11