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PJA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L0B
Identifiers
Aliases	PJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1
External IDs	OMIM: 300420; MGI: 1101765; HomoloGene: 129620; GeneCards: PJA1; OMA:PJA1 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq13.1 Start 69,160,851 bp End 69,165,521 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X C3|X 43.38 cM Start 98,509,340 bp End 98,514,879 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence corpus epididymis ventricular zone nucleus accumbens middle temporal gyrus anterior cingulate cortex dorsolateral prefrontal cortex prefrontal cortex Brodmann area 9 caudate nucleus Top expressed in corneal stroma CA3 field perirhinal cortex entorhinal cortex Ileal epithelium dorsomedial hypothalamic nucleus ventromedial nucleus paraventricular nucleus of hypothalamus arcuate nucleus central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding ubiquitin protein ligase activity transferase activity Cellular component cytoplasm Biological process protein catabolic process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64219 18744 Ensembl ENSG00000181191 ENSMUSG00000034403 UniProt Q8NG27 O55176 RefSeq (mRNA) NM_001032396 NM_022368 NM_145119 NM_001382775 NM_001382776 NM_001083110 NM_001290555 NM_001290556 NM_008853 RefSeq (protein) NP_001027568 NP_071763 NP_660095 NP_001369704 NP_001369705 NP_001076579 NP_001277484 NP_001277485 NP_032879 Location (UCSC) Chr X: 69.16 – 69.17 Mb Chr X: 98.51 – 98.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.

Interactions

PJA1 has been shown to interact with UBE2D2 and MAGED1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000181191 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034403 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
6. "Entrez Gene: PJA1 praja 1".
7. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

Further reading

• Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, et al. (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
• Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (March 2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". The Journal of Biological Chemistry. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
• Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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