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PNU-91356A

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Chemical compound Pharmaceutical compound
PNU-91356A
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • (10R)-10-(propylamino)-1,3-diazatricyclododeca-4,6,8(12)-trien-2-one
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H17N3O
Molar mass231.299 g·mol
3D model (JSmol)
SMILES
  • CCCNC1CC2=C3C(=CC=C2)NC(=O)N3C1
InChI
  • InChI=1S/C13H17N3O/c1-2-6-14-10-7-9-4-3-5-11-12(9)16(8-10)13(17)15-11/h3-5,10,14H,2,6-8H2,1H3,(H,15,17)/t10-/m1/s1
  • Key:XTWUNLMHXDDOMD-SNVBAGLBSA-N

PNU-91356A (U-91356) is a drug used in scientific research which acts as a potent and reasonably selective agonist of the dopamine receptor D2, with lower affinity for the related D3 and D4 subtypes and the 5-HT1A receptor.

See also

References

  1. Moon MW, Morris JK, Heier RF, Hsi RS, Manis MO, Royer ME, et al. (1993). "Medicinal chemistry of imidazoquinolinone dopamine receptor agonists". Drug Design and Discovery. 9 (3–4): 313–22. PMID 8104520.
  2. Piercey MF, Moon MW, Sethy VH, Schreur PJ, Smith MW, Tang AH, Von Voigtlander PF (December 1996). "Pharmacology of U-91356A, an agonist for the dopamine D2 receptor subtype". European Journal of Pharmacology. 317 (1): 29–38. doi:10.1016/s0014-2999(96)00695-4. PMID 8982716.
Dopamine receptor modulators
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists


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