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PPP1R10

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Protein-coding gene in the species Homo sapiens
PPP1R10
Identifiers
AliasesPPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99, protein phosphatase 1 regulatory subunit 10
External IDsOMIM: 603771; MGI: 1289273; HomoloGene: 2033; GeneCards: PPP1R10; OMA:PPP1R10 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)
Chromosome 6 (human)Genomic location for PPP1R10Genomic location for PPP1R10
Band6p21.33Start30,600,413 bp
End30,618,612 bp
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)
Chromosome 17 (mouse)Genomic location for PPP1R10Genomic location for PPP1R10
Band17 B1|17 18.77 cMStart36,227,326 bp
End36,243,175 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • sural nerve

  • gallbladder

  • tonsil

  • granulocyte

  • appendix

  • urinary bladder

  • right uterine tube

  • rectum

  • Achilles tendon
Top expressed in
  • primary oocyte

  • zygote

  • tail of embryo

  • testicle

  • secondary oocyte

  • genital tubercle

  • spermatid

  • spermatocyte

  • ventricular zone

  • uterus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5514

52040

Ensembl
ENSG00000227804
ENSG00000238104
ENSG00000206489
ENSG00000230995
ENSG00000235291

ENSG00000231737
ENSG00000204569

ENSMUSG00000039220

UniProt

Q96QC0

Q80W00

RefSeq (mRNA)

NM_002714
NM_001376195

NM_001163818
NM_175934
NM_001357740

RefSeq (protein)

NP_002705
NP_001363124

NP_001157290
NP_001344669
NP_001390493

Location (UCSC)Chr 6: 30.6 – 30.62 MbChr 17: 36.23 – 36.24 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.

Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.

References

  1. ^ ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 GRCh38: Ensembl release 89: ENSG00000227804, ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000039220Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi:10.1074/jbc.273.7.4089. PMID 9461602.
  6. Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi:10.1006/bbrc.1998.9354. PMID 9784381.
  7. ^ "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

Further reading


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