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PRINS (psoriasis associated RNA induced by stress) is a long non-coding RNA. Its expression is induced by stress, and it may have a protective role in cells exposed to stress. It is over-expressed in the skin of patients with psoriasis. It regulates G1P3, a gene encoding a protein with anti-apoptotic effects in keratinocytes. Overexpression of PRINS may contribute to psoriasis via the down-regulation of G1P3.

See also

• Long noncoding RNA

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Sonkoly E, Bata-Csorgo Z, Pivarcsi A, et al. (June 2005). "Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS". J. Biol. Chem. 280 (25): 24159–24167. doi:10.1074/jbc.M501704200. PMID 15855153.
3. Szegedi K, Sonkoly E, Nagy N, et al. (March 2010). "The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS". Exp. Dermatol. 19 (3): 269–278. doi:10.1111/j.1600-0625.2010.01066.x. PMID 20377629. S2CID 205822988.

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.

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