PTM may refer to:
- Parent-teacher meeting, a meeting of parents with teachers to discuss the progress of school students
- President's Tatrakshak Medal, a military decoration of the Indian Coast Guard
- Pashtun Tahafuz Movement, a human rights movement in Pakistan for the Pashtun people
- Polygyny threshold model, a theory explaining polygyny
- Polynomial texture mapping, a digital imaging technique
- Portugal. The Man, an American rock band
- Post-translational modification, covalent and generally enzymatic modification of proteins following protein biosynthesis by ribosomes
- Post-transition metal, a grouping of chemical elements
- Probabilistic Turing machine
- Pulse-time modulation, an alternative name for Pulse-width modulation
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