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Renal tissue kallikrein (EC 3.4.21.35, glandular kallikrein, pancreatic kallikrein, submandibular kallikrein, submaxillary kallikrein, kidney kallikrein, urinary kallikrein, kallikrein, salivary kallikrein, kininogenin, kininogenase, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, depot-padutin, urokallikrein, dilminal D, onokrein P) is an enzyme.

Renal tissue kallikrein is formed from kidney tissue prokallikrein by activation with the enzyme trypsin. It catalyses the chemical reaction causing preferential cleavage of Arg- bonds in small molecule substrates, acting to highly selectively release kallidin (lysyl-bradykinin, a bioactive kinin) from kininogen (a kinin protein precursor).

References

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5. Kato H, Enjyoji K, Miyata T, Hayashi I, Oh-ishi S, Iwanaga S (February 1985). "Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins". Biochemical and Biophysical Research Communications. 127 (1): 289–95. doi:10.1016/s0006-291x(85)80157-1. PMID 3844939.
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9. Fujinaga M, James MN (May 1987). "Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution". Journal of Molecular Biology. 195 (2): 373–96. doi:10.1016/0022-2836(87)90658-9. PMID 2821276.
10. Kato H, Nakanishi E, Enjyoji K, Hayashi I, Oh-ishi S, Iwanaga S (December 1987). "Characterization of serine proteinases isolated from rat submaxillary gland: with special reference to the degradation of rat kininogens by these enzymes". Journal of Biochemistry. 102 (6): 1389–404. doi:10.1093/oxfordjournals.jbchem.a122185. PMID 3482210.
11. Bailey GS (1989). "Rat pancreas kallikrein". Immunochemical Techniques Part M: Chemotaxis and Inflammation. Methods in Enzymology. Vol. 163. pp. 115–28. doi:10.1016/0076-6879(88)63013-8. ISBN 978-0-12-182064-0. PMID 3237072.
12. Blaber M, Isackson PJ, Marsters JC, Burnier JP, Bradshaw RA (September 1989). "Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland". Biochemistry. 28 (19): 7813–9. doi:10.1021/bi00445a043. PMID 2611215.
13. Chao J, Chao L (1988). "Rat urinary kallikrein". Immunochemical Techniques Part M: Chemotaxis and Inflammation. Methods in Enzymology. Vol. 163. pp. 128–43. doi:10.1016/0076-6879(88)63014-x. ISBN 978-0-12-182064-0. PMID 3070295.
14. Geiger R, Miska W (1988). "[101 Human tissue kallikrein". Immunochemical Techniques Part M: Chemotaxis and Inflammation. Methods in Enzymology. Vol. 163. pp. 102–15. doi:10.1016/0076-6879(88)63012-6. ISBN 978-0-12-182064-0. PMID 3237071.
15. Bertrand R, Derancourt J, Kassab R (March 1989). "Selective cleavage at lysine of the 50 kDa-20 kDa connector loop segment of skeletal myosin S-1 by endoproteinase Arg-C". FEBS Letters. 246 (1–2): 171–6. Bibcode:1989FEBSL.246..171B. doi:10.1016/0014-5793(89)80277-7. PMID 2523317.
16. Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ (May 1989). "Organization and expression of the rat kallikrein gene family". The Journal of Biological Chemistry. 264 (13): 7653–62. doi:10.1016/S0021-9258(18)83284-7. PMID 2708383.
17. Elmoujahed A, Gutman N, Brillard M, Gauthier F (June 1990). "Substrate specificity of two kallikrein family gene products isolated from the rat submaxillary gland". FEBS Letters. 265 (1–2): 137–40. Bibcode:1990FEBSL.265..137E. doi:10.1016/0014-5793(90)80903-v. PMID 2194829.
18. Xiong W, Chen LM, Chao J (February 1990). "Purification and characterization of a kallikrein-like T-kininogenase". The Journal of Biological Chemistry. 265 (5): 2822–7. doi:10.1016/S0021-9258(19)39875-8. PMID 2303430.

External links

• Tissue+kallikrein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 3.4.21