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Protein family
ParE toxin of type II Toxin-anittoxin system
crystal structure of archaeal rele-relb complex from pyrococcus horikoshii ot3
The parDE type II toxin-antitoxin system is one example of the bacterialtoxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin). These systems preferentially guarantee growth of plasmid-carrying daughter cells in a bacterial population by killing newborn bacteria that have not inherited a plasmid copy at cell division (post-segregational killing).
ParD is a plasmid anti-toxin that forms a ribbon-helix-helix DNA bindingstructure. It stabilises plasmids by inhibiting ParE toxicity in cells that express ParD and ParE. ParD forms a dimer and also regulates its own promoter (parDE). As with CcdB the toxin target is DNA gyrase. Induction of ParE toxin results in inhibition of cell division but not cell growth.
The parD and ccD systems are found to be strikingly similar in terms of their structures and actions. The antitoxin protein of each system interacts with its cognate toxin to neutralise the activity of the toxin and in the process the complex of the two becomes an efficient transcription repressor.
crystal structure of archaeal rele-relb complex from pyrococcus horikoshii ot3