Paul O'Brien may refer to:
- Paul O'Brien (scholar) (1763–1820), Irish language scholar and Catholic priest
- Paul O'Brien (Australian footballer, born 1948), VFL footballer for Fitzroy
- Paul O'Brien (Australian footballer, born 1950), VFL footballer for Carlton
- Paul O'Brien (chemist) (1954–2018), professor of chemistry
- Paul O'Brien (Australian footballer, born 1961), VFL footballer for Essendon and Melbourne
- Paul O'Brien (Scottish footballer) (born 1967), Scottish footballer
- Paul O'Brien (equestrian) (born 1968), New Zealand equestrian
- Paul O'Brien (actor) (born 1978), Australian actor
- Paul O'Brien (rugby league), Australian rugby league footballer of the 1970s
If an internal link led you here, you may wish to change the link to point directly to the intended article. Category: