Pennycook is a surname. People with this surname include:
- Alastair Pennycook (born 1957), linguist
- Chevvy Pennycook (born 1985), English rugby union player for Bristol Rugby
- Gordon Pennycook, Canadian psychologist
- Jean Pennycook, American educator and zoologist.
- Matthew Pennycook (born 1982), British Labour Party politician, Member of Parliament (MP) for Greenwich & Woolwich since 2015
- Neil Scott Pennycook, Scottish musician and member of indie rockband Meursault.
- Redford Pennycook (born 1987), English rugby union player for Moseley in the Aviva Championship
- Richard Pennycook (born 1964), British business executive
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