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Pepsin A

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Pepsin A
Pepsin + inhibitor (l.blue), Human
Identifiers
EC no.3.4.23.1
CAS no.9001-75-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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NCBIproteins

Pepsin A (EC 3.4.23.1, pepsin, lactated pepsin, pepsin fortior, fundus-pepsin, elixir lactate of pepsin, P I, lactated pepsin elixir, P II, pepsin R, pepsin D) is an enzyme. This enzyme catalyses the following chemical reaction

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe-Val, Gln-His, Glu-Ala, Ala-Leu, Leu-Tyr, Tyr-Leu, Gly-Phe, Phe-Phe and Phe-Tyr bonds in the B chain of insulin

The enzyme is a predominant endopeptidase in the gastric juice of vertebrates.

See also

References

  1. Lee D, Ryle AP (September 1967). "Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa". The Biochemical Journal. 104 (3): 735–41. PMC 1271213. PMID 4167464.
  2. Lee D, Ryle AP (September 1967). "Pepsin D. A minor component of commercial pepsin preparations". The Biochemical Journal. 104 (3): 742–8. PMC 1271214. PMID 4860638.
  3. Foltmann B (1981). "Gastric proteinases--structure, function, evolution and mechanism of action". Essays in Biochemistry. 17: 52–84. PMID 6795036.
  4. James MN, Sielecki AR (1986). "Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 A resolution". Nature. 319 (6048): 33–8. doi:10.1038/319033a0. PMID 3941737.
  5. Fruton, J.S.; Brocklehurst, K. (1987). "Aspartyl proteinases". In Neuberger, A. (ed.). New Comprehensive Biochemistry: Hydrolytic Enzymes. Vol. 16. Amsterdam: Elsevier. pp. 1–38.
  6. Tang J, Wong RN (January 1987). "Evolution in the structure and function of aspartic proteases". Journal of Cellular Biochemistry. 33 (1): 53–63. doi:10.1002/jcb.240330106. PMID 3546346.
  7. Pohl J, Dunn BM (June 1988). "Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site". Biochemistry. 27 (13): 4827–34. doi:10.1021/bi00413a037. PMID 3139029.

External links

Proteases: aspartate proteases (EC 3.4.23)
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