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Phenylaminotetralin

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Phenylaminotetralin
Names
IUPAC name (2S,4R)-N,N-dimethyl-4-phenyl-1,2,3,4-tetrahydronaphthalen-2-amine
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
InChI
  • InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m1/s1Key: DXJUCAUQIHNOAF-SJLPKXTDSA-N
  • InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m1/s1Key: DXJUCAUQIHNOAF-SJLPKXTDSA-N
SMILES
  • CN(C)1CC(C2=CC=CC=C2C1)C3=CC=CC=C3
Properties
Chemical formula C18H21N
Molar mass 251.373 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Phenylaminotetralins are novel histamine receptor ligands. Binding assays determined that (-)-trans-H2-PAT possessed the strongest binding affinity at the histamine H1 receptor.

References

  1. Booth, RG; Moniri, NH; Bakker, RA; Choksi, NY; Nix, WB; Timmerman, H; Leurs, R (July 2002). "A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors". The Journal of Pharmacology and Experimental Therapeutics. 302 (1): 328–36. doi:10.1124/jpet.302.1.328. PMID 12065734.


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