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Phenylephrine/ketorolac

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Combination drug used during eye surgery

Pharmaceutical compound
Phenylephrine/ketorolac
Combination of
PhenylephrineAlpha-1 adrenergic receptor agonist
KetorolacNonsteroidal anti-inflammatory
Clinical data
Trade namesOmidria
AHFS/Drugs.comMonograph
License data
Routes of
administration
Intraocular
ATC code
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Identifiers
KEGG

Phenylephrine/ketorolac, sold under the brand name Omidria, is a combination drug used during cataract surgery or intraocular lens replacement to prevent intraoperative miosis and to reduce postoperative pain. It contains phenylephrine and ketorolac.

Phenylephrine/ketorolac was approved for medical use in the United States in May 2014, and in the European Union in July 2015.

References

  1. ^ "Omidria- phenylephrine and ketorolac injection, solution, concentrate". DailyMed. 11 December 2017. Retrieved 17 April 2020.
  2. ^ "Omidria EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 17 April 2020.
  3. Lawuyi LE, Gurbaxani A (2015). "The clinical utility of new combination phenylephrine/ketorolac injection in cataract surgery". Clinical Ophthalmology. 9. Auckland, N.Z.: 1249–54. doi:10.2147/OPTH.S72321. PMC 4506037. PMID 26203214.
  4. "Drug Approval Package: Omidria (phenylephrine and ketorolac) Injection NDA #205388". U.S. Food and Drug Administration (FDA). 9 December 2014. Retrieved 17 April 2020.

External links

Ophthalmologicals: mydriasis and cycloplegia (S01F)
Anticholinergics/antimuscarinics
Sympathomimetics
Adrenergic receptor modulators
α1
Agonists
Antagonists
α2
Agonists
Antagonists
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Agonists
Antagonists
Prostanoid signaling modulators
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
EP2Tooltip Prostaglandin EP2 receptor
EP3Tooltip Prostaglandin EP3 receptor
EP4Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
TP (TXA2)Tooltip Thromboxane receptor
Unsorted
Enzyme
(inhibitors)
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(PTGS)
PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthaseHQL-79
PGFSTooltip Prostaglandin F synthaseBimatoprost
PGI2STooltip Prostacyclin synthaseTranylcypromine
TXASTooltip Thromboxane A synthase
Others
See also
Receptor/signaling modulators
Leukotriene signaling modulators
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