Misplaced Pages

Parts of this article (those related to PMID 17658730 and PMID 18425604) need to be updated. Please help update this article to reflect recent events or newly available information. (November 2010)

Phosducin (yellow) - Transducin beta-gamma complex
Identifiers
Symbol	Phosducin
Pfam	PF02114
InterPro	IPR001200
SCOP2	1b9y / SCOPe / SUPFAM
OPM superfamily	131
OPM protein	1b9x
CDD	cd02987
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The outer and inner segments of vertebrate retina rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the guanosine triphosphate-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A. The protein is thought to participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Similar proteins have been isolated from the pineal gland and it is believed that the function of the protein is the same in both retina and pineal gland.

Human proteins containing this domain

References

1. Craft CM, Lee RH, Fowler A, Lolley RN, McGinnis JF (1990). "Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells". J. Biol. Chem. 265 (26): 15867–15873. doi:10.1016/S0021-9258(18)55479-X. PMID 2203790.
2. Takagi T, Abe T, Nakabayashi H, Tamada H, Sakuragi S, Yamaki K, Shinohara T (1990). "Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland". Gene. 91 (2): 209–215. doi:10.1016/0378-1119(90)90090-E. PMID 2210381.

• Protein domains
• Protein families
• Peripheral membrane proteins