1-phosphatidylinositol 4-kinase

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, the structure has only been solved for this enzyme. Part of the enzyme was crystallized with its activating partner frequenin.

References

Strahl T, Huttner IG, Lusin JD, et al. (October 2007). "Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)". J. Biol. Chem. 282 (42): 30949–59. doi:10.1074/jbc.M705499200. PMID 17720810.

Colodzin M, Kennedy EP (1965). "Biosynthesis of diphosphoinositide in brain". J. Biol. Chem. 240 (10): 3771–80. doi:10.1016/S0021-9258(18)97109-7. PMID 4284712.
Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328–37. doi:10.1042/bj1010328. PMC 1270113. PMID 4290722.
Walker DH, Dougherty N, Pike LJ (1988). "Purification and characterization of a phosphatidylinositol kinase from A431 cells". Biochemistry. 27 (17): 6504–11. doi:10.1021/bi00417a046. PMID 2851325.
Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988). "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644–6. Bibcode:1988Natur.332..644W. doi:10.1038/332644a0. PMID 2833705. S2CID 4326568.
Barylko B; Gerber, SH; Binns, DD; Grichine, N; Khvotchev, M; Südhof, TC; Albanesi, JP (2001). "A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans". J. Biol. Chem. 276 (11): 7705–8. doi:10.1074/jbc.C000861200. PMID 11244087.

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase
2.7.2: COOH acceptor	Phosphoglycerate Aspartate kinase
2.7.3: N acceptor	Creatine
2.7.4: PO₄ acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase

DNA-directed DNA polymerase

I/A

Taq

II/B

Pfu

III/C

IV/X

TDT

V/Y

RNA-directed DNA polymerase

Reverse transcriptase

Telomerase

RNA polymerase

Template-directed

RNA-dependent RNA polymerase

Polyadenylation

PAP

PNPase

Phosphorolytic
3' to 5' exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases
2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases
2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases
2.7.13: protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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