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Phosphoserine

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(Redirected from Phosphorylated serine)
l-Phosphoserine
Skeletal formula
Ball-and-stick model
Names
IUPAC name (S)-2-Amino-3-(phosphonooxy)propionic acid
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.006.352 Edit this at Wikidata
EC Number
  • 206-986-0
IUPHAR/BPS
KEGG
MeSH Phosphoserine
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1Key: BZQFBWGGLXLEPQ-REOHCLBHSA-N
  • InChI=1/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
SMILES
  • O=P(O)(O)OC(C(=O)O)N
Properties
Chemical formula C3H8NO6P
Molar mass 185.073 g/mol
Melting point 228 °C (442 °F; 501 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Phosphoserine (abbreviated as SEP or J) is an ester of serine and phosphoric acid. Phosphoserine is a component of many proteins as the result of posttranslational modifications. The phosphorylation of the alcohol functional group in serine to produce phosphoserine is catalyzed by various types of kinases. Through the use of technologies that utilize an expanded genetic code, phosphoserine can also be incorporated into proteins during translation.

It is a normal metabolite found in human biofluids.

Phosphoserine has three potential coordination sites (carboxyl, amine and phosphate group) Determination of the mode of coordination between phosphorylated ligands and metal ions occurring in an organism is a first step to explain the function of the phosphoserine in bioinorganic processes.

References

  1. Olsen, Jesper V.; Blagoev, Blagoy; Gnad, Florian; Macek, Boris; Kumar, Chanchal; Mortensen, Peter; Mann, Matthias (2006-03-11). "Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  2. Krebs, Edwin G. (1985-10-01). "The phosphorylation of proteins: a major mechanism for biological regulation". Biochemical Society Transactions. 13 (5): 813–820. doi:10.1042/bst0130813. PMID 2998902.
  3. Manning, G.; Whyte, D. B.; Martinez, R.; Hunter, T.; Sudarsanam, S. (2002-12-06). "The Protein Kinase Complement of the Human Genome". Science. 298 (5600): 1912–1934. Bibcode:2002Sci...298.1912M. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.
  4. Park, Hee-Sung; Hohn, Michael J.; Umehara, Takuya; Guo, Li-Tao; Osborne, Edith M.; Benner, Jack; Noren, Christopher J.; Rinehart, Jesse; Söll, Dieter (2011-08-26). "Expanding the Genetic Code of Escherichia coli with Phosphoserine". Science. 333 (6046): 1151–1154. Bibcode:2011Sci...333.1151P. doi:10.1126/science.1207203. PMC 5547737. PMID 21868676.
  5. Rogerson, Daniel T; Sachdeva, Amit; Wang, Kaihang; Haq, Tamanna; Kazlauskaite, Agne; Hancock, Susan M; Huguenin-Dezot, Nicolas; Muqit, Miratul M K; Fry, Andrew M (2015-01-01). "Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog". Nature Chemical Biology. 11 (7): 496–503. doi:10.1038/nchembio.1823. PMC 4830402. PMID 26030730.
  6. Oza, Javin P.; Aerni, Hans R.; Pirman, Natasha L.; Barber, Karl W.; ter Haar, Charlotte M.; Rogulina, Svetlana; Amrofell, Matthew B.; Isaacs, Farren J.; Rinehart, Jesse (2015-09-09). "Robust production of recombinant phosphoproteins using cell-free protein synthesis". Nature Communications. 6: 8168. Bibcode:2015NatCo...6.8168O. doi:10.1038/ncomms9168. PMC 4566161. PMID 26350765.
  7. Kataoka, H; Nakai, K; Katagiri, Y; Makita, M (1993). "Analysis of free and bound O-phosphoamino acids in urine by gas chromatography with flame photometric detection". Biomedical Chromatography. 7 (4): 184–8. doi:10.1002/bmc.1130070403. PMID 7693088.
  8. Jastrzab, Renata; Lomozik, Lechoslaw (2009-03-10). "Coordination mode in the binary systems of copper(II)/O-phospho-L-serine". Journal of Coordination Chemistry. 62 (5): 710–720. doi:10.1080/00958970802317855. S2CID 95207026.
  9. Jastrzab, Renata (2009-05-01). "Phosphoserine and specific types of its coordination in copper(II) and adenosine nucleotides systems – Potentiometric and spectroscopic studies". Journal of Inorganic Biochemistry. 103 (5): 766–773. doi:10.1016/j.jinorgbio.2009.01.012. PMID 19230980.
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