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In enzymology, a phylloquinone monooxygenase (2,3-epoxidizing) (EC 1.14.99.20) is an enzyme that catalyzes the chemical reaction

phylloquinone + AH₂ + O₂ ${\displaystyle \rightleftharpoons }$ 2,3-epoxyphylloquinone + A + H₂O

The three substrates of this enzyme are phylloquinone, an electron acceptor AH₂, and O₂, whereas its three products are 2,3-epoxyphylloquinone, the reduction product A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing). Other names in common use include phylloquinone epoxidase, vitamin K 2,3-epoxidase, vitamin K epoxidase, and vitamin K₁ epoxidase.

References

• Willingham AK, Matschiner JT (1974). "Changes in phylloquinone epoxidase activity related to prothrombin synthesis and microsomal clotting activity in the rat". Biochem. J. 140 (3): 435–41. PMC 1168020. PMID 4155625.

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