Picciotto may refer to:
People
- Concepción Picciotto (1936–2016), Spanish-American peace activist
- Cyril Moses Picciotto (1888–1940), British barrister, writer and politician
- Danielle de Picciotto, American-born artist, musician and film maker in Germany
- Edgar de Picciotto, Swiss banker
- Guy Picciotto (born 1965), American singer, songwriter, guitarist, musician, and producer
- Irva Hertz-Picciotto (born 1948), American environmental epidemiologist
- Marina Picciotto (born 1963), American neuroscientist
- Joseph de Picciotto Bey (1872–1938), Egyptian senator and economist
- Nora Picciotto (born 1942), Egyptian noble and model
- Sol Picciotto (born 1942), British professor of law
Other uses
- Picciotto (Mafia), a rank of Mafia associate
- Mount Picciotto, a mountain in Antarctica
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