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PRKX
Identifiers
Aliases	PRKX, PKX1, protein kinase, X-linked, protein kinase X-linked
External IDs	OMIM: 300083; MGI: 1309999; HomoloGene: 55868; GeneCards: PRKX; OMA:PRKX - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp22.33 Start 3,604,340 bp End 3,713,649 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X B Start 76,805,017 bp End 76,839,884 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence monocyte left lobe of thyroid gland right lobe of thyroid gland right uterine tube granulocyte skin of abdomen skin of leg endometrium right lung Top expressed in lumbar spinal ganglion olfactory epithelium ascending aorta gastrula aortic valve trigeminal ganglion blood decidua conjunctival fornix submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cAMP-dependent protein kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytoplasm nucleus Biological process myeloid cell differentiation cell differentiation regulation of cell migration phosphorylation epithelial tube morphogenesis multicellular organism development protein phosphorylation cell-substrate adhesion regulation of cell adhesion cell adhesion peptidyl-serine phosphorylation endothelial cell proliferation kidney morphogenesis angiogenesis protein autophosphorylation endothelial cell migration regulation of epithelial cell differentiation involved in kidney development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5613 19108 Ensembl ENSG00000183943 ENSMUSG00000035725 UniProt P51817 Q922R0 RefSeq (mRNA) NM_005044 NM_016979 RefSeq (protein) NP_005035 NP_005035.1 NP_058675 Location (UCSC) Chr X: 3.6 – 3.71 Mb Chr X: 76.81 – 76.84 Mb PubMed search
Wikidata
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Protein kinase, X-linked is a protein that in humans is encoded by the PRKX gene.

Function

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y.

Nomenclature

Mouse ortholog for this gene, Prkx, is also known as Pkare.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000183943 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000035725 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Protein kinase, X-linked". Retrieved 2017-05-19.
6. "Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]". National Center for Biotechnology Information.

Further reading

• Li X, Li HP, Amsler K, Hyink D, Wilson PD, Burrow CR (2002). "PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9260–5. Bibcode:2002PNAS...99.9260L. doi:10.1073/pnas.132051799. PMC 123128. PMID 12082174.
• Li X, Burrow CR, Polgar K, Hyink DP, Gusella GL, Wilson PD (2008). "Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency" (PDF). Biochim. Biophys. Acta. 1782 (1): 1–9. doi:10.1016/j.bbadis.2007.09.003. PMID 17980165. S2CID 23224610.
• Li X, Iomini C, Hyink D, Wilson PD (2011). "PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation". Dev. Biol. 356 (2): 475–85. doi:10.1016/j.ydbio.2011.05.673. PMID 21684272.
• Lin Y, Li W (2011). "MBD 4--a potential substrate for protein kinase X". Acta Biochim. Biophys. Sin. (Shanghai). 43 (11): 916–7. doi:10.1093/abbs/gmr086. PMID 21971312.
• Bender C, Ullrich A (2012). "PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines". Int. J. Cancer. 131 (2): E45–55. doi:10.1002/ijc.26486. PMID 22020623. S2CID 27590197.
• Huang S, Li Q, Alberts I, Li X (2016). "PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development". J. Cell. Biochem. 117 (3): 566–73. doi:10.1002/jcb.25304. PMID 26252946. S2CID 45734891.

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