Plasmepsin I

Identifiers

Databases

PDB structures

Plasmepsin I (EC 3.4.23.38, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme. This enzyme catalyses the following chemical reaction

Hydrolysis of the -Phe-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule

This enzyme is present in the malaria organism, Plasmodium.

References

Goldberg DE, Slater AF, Beavis R, Chait B, Cerami A, Henderson GB (April 1991). "Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease". The Journal of Experimental Medicine. 173 (4): 961–9. doi:10.1084/jem.173.4.961. PMC 2190804. PMID 2007860.
Francis SE, Gluzman IY, Oksman A, Knickerbocker A, Mueller R, Bryant ML, Sherman DR, Russell DG, Goldberg DE (January 1994). "Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase". The EMBO Journal. 13 (2): 306–17. doi:10.1002/j.1460-2075.1994.tb06263.x. PMC 394809. PMID 8313875.
Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE (April 1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". The Journal of Clinical Investigation. 93 (4): 1602–8. doi:10.1172/JCI117140. PMC 294190. PMID 8163662.

Plasmepsin+I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Proteases: aspartate proteases (EC 3.4.23)
Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2
Pathogenic	Plasmepsin HIV-1 protease
Plant	Nepenthesin
Cathepsin	D E

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)