Plaza Mayor may refer to:
- Plaza Mayor (shopping center) in León, Guanajuato state, Mexico
- Plaza mayor (urban design), in Spanish-speaking countries, a major city square
- Plaza Mayor, Madrid, a plaza in the centre of Madrid, Spain
- Plaza Mayor, Valladolid, a plaza in the centre of Valladolid, Spain
- Plaza Mayor, Salamanca, a plaza in the centre of Salamanca, Spain
- Plaza Mayor, Lima, a plaza in the centre of Lima, Perú
- Plaza de Roma, a plaza in the centre of Manila
- Plaza Mayor, Trinidad, Cuba, a plaza in the center of Trinidad, Cuba
- Plaza Mayor, Medellín, a conventions center in Medellín, Colombia
- Plaza Mayor (Oklahoma), formerly Crossroads Mall, a mall in Oklahoma City, United States
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