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Pleuran

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Pleuran
Identifiers
CAS Number
ChemSpider
  • none
Properties
Chemical formula (C6H10O5)x
Molar mass Variable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Pleuran is an insoluble polysaccharide (β-(1,3/1,6)-D-glucan), isolated from Pleurotus ostreatus.

Pleuran belongs to a group of glucose polymers commonly called beta-glucans demonstrating biological response modifier properties. These immunomodulating properties render the host more resistant to infections and neoplasms.

In a study published in December 2010, pleuran demonstrated to have a protective effect against exercise-induced suppression of immune cell activity (NK cells) in subjects taking 100 mg per day.

In another study published in 2011, pleuran reduced the incidence of upper respiratory tract infections and increased the number of circulating NK cells.

Pleuran is also being studied as a potential immunologic adjuvant.

References

  1. Karácsonyi S, Kuniak L (1994). "Polysaccharides of Pleurotus ostreatus: Isolation and structure of pleuran, an alkali-insoluble β-glucan". Carbohydrate Polymers. 24 (2). Elsevier: 107–111. doi:10.1016/0144-8617(94)90019-1.
  2. Di Luzio, NR (1985). "Update on the immunomodulating activities of glucans". Springer Seminars in Immunopathology. 8 (4). Germany: Springer Verlag: 387–400. doi:10.1007/BF01857392. PMID 4089757. S2CID 24803241.
  3. Bobovčák, M; Kuniaková, R, Gabriž, J, Majtán, J (December 2010). "Effect of Pleuran (β-glucan from Pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes". Applied Physiology, Nutrition, and Metabolism. 35 (6): 755–62. doi:10.1139/h10-070. PMID 21164546.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Bergendiova, K; Tibenska, E, Majtan, J (2011-01-20). "Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes". European Journal of Applied Physiology. 111 (9): 2033–40. doi:10.1007/s00421-011-1837-z. PMID 21249381. S2CID 25411018.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Vogel FR, Powell MF, Alving CR (1998). "A Compendium of Vaccine Adjuvants and Excipients" (PDF). Pharmaceutical Biotechnology. 2nd ed. 6. National Institute of Allergy and Infectious Diseases: 141–228. doi:10.1007/978-1-4615-1823-5_7. ISBN 978-1-4613-5737-7. PMID 7551218. Archived (PDF) from the original on 2007-07-15. Retrieved 2008-05-08.


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