Plica may refer to:
- Plica (lizard), a genus of lizards
- Capillaria plica, a parasitic nematode
- Plica (sigillography) - term from sigillography
- A fold or crease, especially of skin or other tissue, from medieval Latin plicare ("to fold")
- Plica fimbriata: Fimbriated fold of tongue
- Plica semilunaris of the conjunctiva
- Plica semilunaris of the fauces
- Plica syndrome of the knee
- Plica circularis, also called circular fold, of the small intestine
- The hair disease Plica polonica: Polish plait
- In early music notation, a note indicated in a ligature
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