Misplaced Pages

Plithotaxis

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Tendency of cells to migrate along the local axis of principal stress
Animation of plithotaxis in action

In cellular biology, plithotaxis (from Greek πλήΘος (plíthos) 'crowd, swarm') is the tendency for each individual cell within a monolayer to migrate along the local orientation of the maximal principal stress, or equivalently, minimal intercellular shear stress. Plithotaxis requires force transmission across many cell-cell junctions and therefore is an emergent property of the cell group.

Plithotaxis is found to hold at the level of both a subcellular grid point and an individual cell of a confluent monolayer, and the stresses must be tensile.

See also

References

  1. Tambe, D.T., Hardin, C., Angelini, T.E., Rajendran, K., Park, C.Y., Serra-Picamal, X., Zhou, E.H., Zaman, M.H., Butler, J.P., Weitz, D.A., Fredberg JJ, Trepat, X, Collective cell guidance by cooperative intercellular forces. Nature Materials,10(6), 469-475, 2011, doi:10.1038/nmat3025.
  2. Gov, N. Cell mechanics: Moving under peer pressure. Nature Materials, 10(6), 412-414, 2011, doi:10.1038/nmat3036.
  3. Trepat, X, Fredberg, JJ. Plithotaxis and emergent dynamics in collective cellular migration. Trends in Cell Biology - 23 July 2011, doi:10.1016/j.tcb.2011.06.006.
  4. Patel, N.G., Nguyen, A., Xu, N., Ananthasekar, S., Alvarez, D.F., Stevens, T., Tambe, D.T., Unleashing shear: Role of intercellular traction and cellular moments in collective cell migration. Biochemical and Biophysical Research Communications - February 2020, doi:10.1016/j.bbrc.2019.11.048.


Stub icon

This cell biology article is a stub. You can help Misplaced Pages by expanding it.

Categories: